TMEM18 Activators
TMEM18, short for Transmembrane Protein 18, is a protein encoded by the TMEM18 gene in humans. It has been intriguingly linked with the regulation of body weight, leading to associations with obesity. Moreover, TMEM18 is considered to play a role in neural processes, suggesting it might have a role in neurodevelopment or the regulation of energy balance. Its exact biological function, however, remains somewhat elusive, yielding a wide array of research opportunities to gain a deeper understanding of this protein. The expression of TMEM18, like many other proteins, could be altered or induced by a variety of chemical compounds, leading to an increase in its production.
A number of chemical compounds have been proposed to stimulate TMEM18 expression. Retinoic Acid, an active metabolite of vitamin A, Forskolin, which upregulates the activity of adenylyl cyclase, and 3,3',5-Triiodo-L-thyronine (T3), a potent thyroid hormone, are among such compounds. Other examples include Dexamethasone, a glucocorticoid that can stimulate the transcription of specific genes, and Metformin, known to increase the activity of AMP-activated protein kinase (AMPK). Resveratrol, Pioglitazone, and Rosiglitazone are also listed, with the latter two being PPAR-gamma agonists. Curcumin, Epigallocatechin gallate (EGCG), Sodium Butyrate, and 5-Aza-2'-deoxycytidine are other compounds hypothesized to induce the expression of TMEM18. These compounds are thought to interact with various cellular pathways to increase TMEM18 expression, though it is important to note that this is a speculative list based on generalized actions these compounds are known for in the context of cellular biochemistry and gene regulation. Future research will likely provide more insights into the complex interplay between these compounds and TMEM18 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, as an active metabolite of vitamin A, could potentially stimulate TMEM18 gene expression by driving cell differentiation and growth. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin upregulates the activity of adenylyl cyclase, leading to an increase in cAMP levels. This could induce the expression of TMEM18 through the activation of cAMP response element-binding protein (CREB). | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
T3, a potent thyroid hormone, could enhance TMEM18 expression by binding to thyroid hormone receptors, which then interact with DNA to stimulate the transcription of target genes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, may upregulate TMEM18 gene expression by activating the glucocorticoid receptor, a nuclear receptor that can stimulate the transcription of specific genes. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin can increase the activity of AMP-activated protein kinase (AMPK), which could lead to the upregulation of TMEM18 by promoting transcriptional changes in energy metabolism genes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can stimulate the activity of sirtuins, especially SIRT1. This action could potentially upregulate the expression of TMEM18 by altering the transcription of genes involved in fat storage and metabolism. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, as a PPAR-gamma agonist, can potentially increase TMEM18 expression by stimulating the transcription of genes involved in glucose and lipid metabolism. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, similar to pioglitazone, could induce the expression of TMEM18 by activating PPAR-gamma, leading to changes in transcription profiles related to metabolic pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may potentially stimulate TMEM18 gene expression through its interactions with various signaling pathways, particularly those involving NF-kB, a key player in inflammation and cell survival. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a major catechin in green tea, may enhance TMEM18 expression through its interactions with multiple pathways, including those related to oxidative stress. | ||||||