TMEM178 Activators
TMEM178 Activators encompass an array of chemical compounds that indirectly facilitate the functional upregulation of TMEMTMEM178. Forskolin, by raising intracellular cAMP levels, indirectly promotes TMEM178 activity by activating protein kinase A (PKA), which then phosphorylates substrates potentially interacting with TMEM178, thus affecting calcium homeostasis and immunological functions. Similarly, Resveratrol activates SIRT1, which in turn could deacetylate proteins and modify their function, leading to the enhancement of TMEM178's role in immune system regulation. Sphingosine-1-phosphate specifically targets S1P receptors that are critical in calcium signaling, which is a pathway where TMEM178 plays a significant role, suggesting its activity could be enhanced through this lipid signaling modulation. Compounds like 8-Bromo-cAMP and Dibutyryl cAMP, both cAMP analogs, stimulate PKA and are presumed to enhance TMEM178 by promoting phosphorylation events central to TMEM178's regulatory functions.
In addition to these, activators such as PMA and Ionomycin leverage protein kinase C (PKC) and calcium ionophores, respectively, to modulate the intracellular environment in a way that is conducive to enhanced TMEM178 activity. PMA's activation of PKC could lead to phosphorylation of proteins within TMEM178-related pathways, while Ionomycin raises intracellular calcium, which is a known regulator of TMEM178-associated signaling. A23187 and Thapsigargin, both of which alter calcium dynamics, either by direct ionophore action or by inhibiting calcium ATPases, would also indirectly promote TMEM178 activity by impacting the calcium-dependent signaling pathways. Rolipram and LY294002 exert their effects by increasing cAMP and inhibiting PI3K, respectively, thereby influencing the activity of TMEM178 through modifications in secondary messenger availability and downstream signaling pathways. Finally, BAPTA-AM, by chelating intracellular calcium, provides a nuanced balance to calcium signaling, indirectly enhancing TMEM178's role in this context.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels in cells. Elevated cAMP activates PKA, which could enhance TMEM178 activity by phosphorylating proteins that interact with TMEM178, thereby influencing calcium homeostasis and immune responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate SIRT1, which can deacetylate proteins and influence their activity. SIRT1 activation might enhance TMEM178 function by modifying acetylation status of proteins involved in the signaling pathways where TMEM178 is active, particularly in immune regulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) binds to S1P receptors, initiating signaling cascades that regulate calcium flux. TMEM178's role in calcium homeostasis could be indirectly enhanced by S1P through the modulation of calcium-related signaling pathways. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
As a cAMP analog, 8-Bromo-cAMP mimics the action of cAMP and activates PKA. This activation could enhance TMEM178 activity by PKA-mediated phosphorylation events that modulate cellular processes such as calcium signaling and immune response in which TMEM178 is implicated. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator. PKC can phosphorylate various proteins and influence numerous signaling pathways. Through the activation of PKC, PMA may indirectly enhance TMEM178 activity by altering signaling pathways that govern calcium homeostasis and immune cell function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels. By elevating calcium, ionomycin could indirectly enhance TMEM178 activity, considering TMEM178's involvement in calcium-dependent signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels. This increase may indirectly enhance TMEM178 activity by affecting calcium signaling pathways relevant to TMEM178's function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to elevated cAMP levels. Increased cAMP may enhance TMEM178 activity by activating PKA, subsequently affecting phosphorylation states of proteins in pathways associated with TMEM178. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is another cAMP analog that activates PKA. This activation could enhance the activity of TMEM178 by phosphorylation of key proteins involved in signaling pathways regulated by TMEM178, particularly in immune cells. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that can indirectly modulate intracellular calcium dynamics. Modifying calcium levels could enhance TMEM178's role in calcium signaling by affecting the cellular context in which TMEM178 operates. | ||||||