TM7SF2 Activators
TM7SF2 play a pivotal role in the modulation of the cholesterol biosynthesis pathway. For instance, 25-Hydroxycholesterol serves as a regulatory molecule, enhancing the expression of enzymes in this pathway by activating sterol regulatory element-binding proteins. The activation cascade that follows can lead to an increase in TM7SF2 activity, as this enzyme is integral in converting lanosterol to cholesterol. Geranylgeraniol, as a precursor for isoprenoid biosynthesis, supplies necessary substrates that are essential for TM7SF2 function within the pathway. It ensures that TM7SF2 has the required components to facilitate cholesterol synthesis. Similarly, mevalonic acid directly contributes to the mevalonate pathway, bolstering the synthesis of cholesterol by providing substrates that TM7SF2 uses in its enzymatic role.
Farnesyl diphosphate and isopentenyl pyrophosphate are intermediates in the same pathway, with each compound fulfilling a crucial role by supplying substrates for subsequent enzymatic reactions that contribute to the overall pathway functionality, indirectly supporting TM7SF2 activity. Squalene, which is a direct substrate for the enzyme immediately upstream of TM7SF2, ensures the flow of necessary molecules towards TM7SF2, facilitating its activation and function. Lanosterol, another direct precursor in the cholesterol biosynthesis pathway, activates enzymes involved in its conversion to cholesterol, including TM7SF2. Additionally, solanesol, though primarily involved in coenzyme Q synthesis, can influence the broader spectrum of the cholesterol biosynthetic pathway, possibly affecting TM7SF2 activity due to its role in the synthesis of polyisoprenoids. Oxysterols, which are known to regulate cholesterol homeostasis, can also affect TM7SF2 by modulating gene expression through liver X receptor activation, which in turn can result in an upregulation of TM7SF2 activity. This intricate network of biochemical interactions ensures that TM7SF2 is supplied with the necessary substrates and regulatory signals for its activation and proper function within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $52.00 $89.00 $166.00 $465.00 | 8 | |
25-Hydroxycholesterol is known to activate sterol regulatory element-binding proteins (SREBPs) which in turn enhance the expression of enzymes involved in cholesterol biosynthesis. TM7SF2 is involved in cholesterol biosynthesis and is a target of SREBP regulation. The activation of SREBPs by this oxysterol leads to the activation of TM7SF2, as it is a crucial enzyme in the sterol biosynthetic pathway. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $159.00 $465.00 | 14 | |
Geranylgeraniol is a precursor for the biosynthesis of isoprenoids and is involved in the post-translational modification of proteins through prenylation. TM7SF2 is involved in the synthesis of isoprenoids as part of the cholesterol biosynthesis pathway. By providing a substrate for isoprenoid synthesis, geranylgeraniol supports the functional activation of TM7SF2 by ensuring the availability of necessary substrates for cholesterol and isoprenoid production. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin is a statin that inhibits the enzyme HMG-CoA reductase, which leads to upregulation of enzymes downstream in the cholesterol biosynthesis pathway as a compensatory mechanism. Although simvastatin itself is an inhibitor, its action results in a compensatory increase in the activity of TM7SF2, as the cell attempts to restore cholesterol synthesis. | ||||||
Farnesyl pyrophosphate ammonium salt | 13058-04-3 | sc-200847 sc-200847A | 1 mg 5 mg | $469.00 $1938.00 | ||
Farnesyl diphosphate is an intermediate in the mevalonate pathway and serves as a substrate for squalene synthase, which is directly upstream of TM7SF2 in the cholesterol biosynthesis pathway. The presence of farnesyl diphosphate ensures the continuation of the cholesterol biosynthesis pathway, indirectly supporting the activation of TM7SF2. | ||||||
Squalene | 111-02-4 | sc-281155 sc-281155A sc-281155B | 10 ml 100 ml 500 ml | $48.00 $90.00 $211.00 | 1 | |
Squalene is a direct substrate for squalene epoxidase, the enzyme immediately upstream of TM7SF2 in the cholesterol biosynthesis pathway. The availability of squalene can lead to increased activity of squalene epoxidase, which in turn ensures the flow of substrates towards TM7SF2, thereby activating its enzymatic function in the pathway. | ||||||
Lanosterol | 79-63-0 | sc-215229 sc-215229A | 1 mg 5 mg | $103.00 $343.00 | 2 | |
Lanosterol is synthesized from squalene and is a direct precursor to cholesterol in the biosynthesis pathway. The presence of lanosterol can stimulate the activity of enzymes involved in its conversion to cholesterol, including TM7SF2, which is responsible for a key step in this process. | ||||||