TINP1 Activators
TINP1 Activators are a class of chemicals which influence the functional activity of the TINP1 protein primarily through modulation of the cyclic AMP (cAMP) pathway, a signaling mechanism that TINP1 is directly involved in. TINP1 is embedded within the cAMP signaling system, hence, chemicals that can influence this system are deemed crucial in enhancing the activity of TINP1. Compounds such as Forskolin and Rolipram function by increasing the concentration of cAMP, this directly enhances TINP1 activity. Forskolin does this by activating adenylate cyclase, leading to elevated cAMP levels, while Rolipram inhibits phosphodiesterase 4, preventing cAMP degradation and therefore increasing its levels. Similarly, IBMX and 8-Bromo-cAMP raise cAMP levels, thereby providing an environment conducive for TINP1 to function optimally.
On the other hand, compounds like Epinephrine and NECA, although they indirectly influence cAMP levels, can still enhance the activity of TINP1. Epinephrine stimulates the beta-adrenergic receptor, a G-protein coupled receptor, which then influences cAMP production. NECA, an adenosine receptor agonist, also impacts cAMP levels indirectly. BAY 60-6583, another adenosine receptor agonist, similarly leads to increased cAMP production. PGE2 activates the prostaglandin E2 receptors leading to increased cAMP levels. ZM 241385, an antagonist of the adenosine A2A receptor, modulates adenosine receptor activity, thereby indirectly enhancing TINP1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent adenylate cyclase activator which increases cyclic AMP levels. TINP1 has been implicated in cAMP signaling, and an elevation in cAMP can enhance the activity of TINP1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), preventing the degradation of cAMP. This leads to increased cAMP levels, potentially enhancing TINP1 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor, increasing cAMP and cGMP levels. This could indirectly enhance the activity of TINP1 through the cAMP pathway. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This is a cell-permeable cAMP analog. Given TINP1's role in cAMP signaling, increasing cAMP levels with this compound could enhance TINP1 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine stimulates the beta-adrenergic receptor, subsequently increasing cAMP levels and potentially enhancing TINP1 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 activates the prostaglandin E2 receptors leading to increased cAMP levels, potentially enhancing TINP1 activity. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ22536 is an adenylate cyclase inhibitor. Although it inhibits cAMP production, in the presence of overactive cAMP signaling, it can restore balance and indirectly enhance TINP1 activity. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an adenosine A2B receptor agonist, which leads to increased cAMP production and potentially enhancing TINP1 activity. | ||||||
ZM 241385 | 139180-30-6 | sc-361421 sc-361421A | 5 mg 25 mg | $92.00 $356.00 | 1 | |
ZM 241385 is a potent antagonist of the adenosine A2A receptor. By modulating adenosine receptor activity, this compound could indirectly enhance TINP1 activity via cAMP signaling. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a selective phosphodiesterase 3 (PDE3) inhibitor, thereby raising intracellular cAMP levels and potentially enhancing TINP1 activity. | ||||||