Testican-3 Activators
Testican-3, also recognized by its scientific name SPOCK3, is an intriguing proteoglycan that plays a crucial role in the composition of the extracellular matrix (ECM). As a member of the testican family, it is implicated in various biological processes, including tissue remodeling and cell-to-matrix interactions. The gene expression of Testican-3 is a complex process that can be influenced by a diverse array of molecular signals and environmental factors. Research into the regulation of Testican-3 is ongoing and has highlighted several chemical compounds that can potentially elevate its expression levels. Understanding the precise mechanisms behind the modulation of Testican-3 is essential for elucidating its role in the ECM and its involvement in the intricate network of cellular communication.
Compounds known as activators can induce the expression of Testican-3 by interacting with cellular signaling pathways and regulatory proteins. For example, retinoic acid, a metabolite of vitamin A, can bind to specific nuclear receptors, initiating a cascade of events that lead to the upregulation of gene transcription, including that of Testican-3. Similarly, agents such as forskolin act on cellular enzymes like adenylate cyclase, leading to increased cyclic AMP (cAMP) levels and the activation of protein kinase A (PKA), which then stimulates the transcription of target genes. Other compounds, such as the histone deacetylase inhibitors trichostatin A and sodium butyrate, exert their effects by modifying the chromatin structure, thereby making the DNA more accessible for transcription factors. Furthermore, elements like lithium chloride can indirectly promote Testican-3 expression by modulating pathways like GSK-3 and Wnt, which are instrumental in cellular signaling and gene regulation. These examples underscore the myriad of molecules that can potentially serve as activators of Testican-3 expression, each with unique molecular targets and mechanisms of action, contributing to the dynamic regulation of the ECM and its components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may upregulate Testican-3 by binding to retinoic acid receptors that directly stimulate the transcription of genes involved in extracellular matrix formation and neurodevelopment. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inducing DNA demethylation, 5-Azacytidine could increase Testican-3 synthesis by reactivating its gene promoter, potentially reversing epigenetic silencing mechanisms. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may elevate Testican-3 levels by stimulating the adenylate cyclase pathway, resulting in increased cAMP, which in turn can initiate the transcription of genes responsible for extracellular matrix production. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA could stimulate Testican-3 expression by activating protein kinase C, which may trigger a signaling cascade culminating in the enhancement of gene transcription related to the extracellular matrix. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might boost Testican-3 expression by engaging glucocorticoid receptors, which can bind to glucocorticoid response elements in the Testican-3 gene promoter. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A has the potential to induce Testican-3 by inhibiting histone deacetylases, leading to a more open chromatin structure and promoting the transcription of genes including those coding for proteoglycans. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate may upregulate Testican-3 by inhibiting histone deacetylases, which leads to hyperacetylation of histones and enhanced transcriptional activation of genes, including those for extracellular proteins. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
As a synthetic nonsteroidal estrogen, Diethylstilbestrol could stimulate Testican-3 production by mimicking estrogen and binding to estrogen receptors that directly upregulate gene expression related to cell growth. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may increase Testican-3 levels by inhibiting GSK-3, leading to activation of the Wnt signaling pathway and subsequent stimulation of genes involved in the extracellular matrix synthesis. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its hormonally active form, might promote Testican-3 synthesis by interacting with vitamin D receptors that can then initiate transcription of genes crucial for extracellular matrix remodeling. | ||||||