TCF-4 Inhibitors
Common TCF-4 Inhibitors include, but are not limited to Calphostin C CAS 121263-19-2, PKF118-310 CAS 84-82-2, Cercosporin CAS 35082-49-6, PNU-74654 CAS 113906-27-7 and BML-286 CAS 294891-81-9.
TCF-4 inhibitors belong to a class of compounds designed to selectively target and inhibit the function of TCF-4 (T-cell factor 4), a transcription factor that plays a significant role in regulating gene expression. TCF-4 is a member of the TCF/LEF family of transcription factors and is a crucial component of the Wnt signaling pathway. This pathway is involved in various cellular processes, including cell proliferation, differentiation, and development. TCF-4 interacts with β-catenin, another key player in the Wnt pathway, to modulate the expression of target genes.
Inhibiting TCF-4 aims to disrupt its interaction with β-catenin, thus altering the downstream gene expression patterns regulated by this complex. By doing so, TCF-4 inhibitors can affect cellular processes that are influenced by the Wnt signaling pathway, including embryonic development, tissue homeostasis, and stem cell maintenance. The development of TCF-4 inhibitors provides researchers with a tool to study the specific role of TCF-4 in various biological contexts and to unravel the complex mechanisms by which the Wnt signaling pathway contributes to normal physiological processes and disease states.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C is a small molecule that could inhibit TCF-4 by disrupting its interaction with β-catenin, thereby affecting Wnt signaling and downstream gene expression. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $180.00 $651.00 | ||
PKF118-310 is another small molecule that might interact with TCF-4 and β-catenin, potentially modulating Wnt signaling and gene transcription. | ||||||
LF3 | 664969-54-4 | sc-507526 | 10 mg | $160.00 | ||
LF3 is a compound that could interfere with TCF-4's binding to β-catenin, potentially affecting Wnt signaling and gene transcription. | ||||||
Cercosporin | 35082-49-6 | sc-255013 | 5 mg | $459.00 | 1 | |
Cercosporin is a small molecule that could potentially inhibit TCF-4's interaction with β-catenin, affecting Wnt signaling and gene transcription. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $131.00 $495.00 | 7 | |
PNU-74654 is a compound that could inhibit TCF-4's interaction with β-catenin, potentially impacting Wnt signaling and gene transcription. | ||||||
BML-286 | 294891-81-9 | sc-397017 | 10 mg | $214.00 | ||
3289-8625 is a potential TCF-4 inhibitor that might affect its interaction with β-catenin, influencing Wnt signaling and gene expression. | ||||||