TAAR6 Inhibitors
TAAR6 inhibitors are a class of compounds that selectively inhibit the activity of the trace amine-associated receptor 6 (TAAR6), a G-protein coupled receptor (GPCR) belonging to the TAAR family. This family of receptors is primarily responsive to trace amines, which are small biogenic amines found in low concentrations within the nervous system and other tissues. TAAR6, like other TAAR receptors, plays a role in modulating intracellular signaling cascades in response to these amines. TAAR6 inhibitors work by binding to the receptor, either at its primary ligand-binding site or at allosteric sites, thereby preventing the receptor from being activated by endogenous ligands. The result of this inhibition is a disruption of the downstream signaling events typically mediated by TAAR6, which may involve changes in levels of cyclic AMP (cAMP) or other second messengers that regulate cellular activities.
The chemical nature of TAAR6 inhibitors can vary, ranging from small organic molecules to more complex synthetic or natural compounds. These inhibitors may exert their effects through different mechanisms, such as competitive antagonism, where they directly compete with trace amines for binding to the receptor's active site, or through allosteric inhibition, where they bind to distinct sites on the receptor to alter its function indirectly. Inhibiting TAAR6 can affect various GPCR-mediated signaling pathways, potentially altering processes such as intracellular calcium flux or other cellular responses. Understanding how TAAR6 inhibitors function provides insight into the broader role of trace amine receptors in physiological systems, as well as the unique signaling pathways associated with TAAR6. This contributes to the larger body of knowledge regarding the functional diversity of TAAR receptors and the significance of trace amine signaling across different tissues.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole impairs thyroid hormone production by inhibiting the enzyme thyroid peroxidase, leading to reduced thyroid hormone levels that could downregulate TAAR6 expression, as thyroid hormones are known to influence neural gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1, which is involved in the deacetylation of histones, potentially leading to the repression of TAAR6 gene transcription due to changes in chromatin structure and accessibility. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine blocks dopamine receptors, which may lead to decreased intracellular cAMP levels, resulting in reduced transcriptional activity of genes including TAAR6 that are cAMP responsive. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol's antagonism of dopamine receptors could lead to diminished dopaminergic neurotransmission and a consequent decrease in the expression of dopamine-regulated genes such as TAAR6. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB, a transcription factor that, when activated, might otherwise initiate the transcription of a variety of genes, potentially including TAAR6. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors which then bind to retinoic acid response elements (RARE) in the DNA, this could repress TAAR6 transcription if RARE is present in its promoter region. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is crucial for cap-dependent translation initiation; this inhibition could result in the selective decrease of the synthesis of proteins like TAAR6. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3β, which can lead to altered phosphorylation of transcription factors, potentially resulting in the downregulation of TAAR6 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate's action as a histone deacetylase inhibitor can lead to hyperacetylation of histones, thereby repressing transcription of genes including TAAR6 by altering chromatin structure. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin suppresses the activity of certain inflammatory cytokines that can be involved in the transcriptional activation of genes; this suppression may extend to the TAAR6 gene, thereby decreasing its expression. | ||||||