T2R44 Activators

T2R44, also known as Taste Receptor Type 2 Member 44, is a protein that is encoded by the TAS2R44 gene in humans. It belongs to the family of taste receptors, specifically the type 2 taste receptors, which are responsible for the sensation of bitterness.Taste receptors are G protein-coupled receptors (GPCRs), a large family of proteins that play critical roles in cellular signal transduction. When a bitter substance binds to T2R44, it triggers a cascade of intracellular signals that eventually result in the perception of bitterness in the brain.

T2R44, like other type 2 taste receptors, is primarily expressed in the taste buds of the tongue. However, recent research has shown that these receptors can also be found in other tissues, challenging the traditional view that their function is limited to taste perception. For instance, they have been identified in the gastrointestinal tract, respiratory system, and the brain, suggesting they may play roles in various physiological processes.In the context of disease, variations in TAS2R44 and other taste receptor genes can influence individual taste perception and dietary choices, which in turn can impact health outcomes. For instance, a heightened sensitivity to bitterness may lead to reduced vegetable intake and a higher risk of certain lifestyle-related diseases.