Date published: 2025-10-25

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T2R38 Inhibitors

T2R38, a bitter taste receptor predominantly expressed in the oral cavity, plays a crucial role in detecting bitter compounds and initiating taste-related signaling cascades. While direct inhibitors of T2R38 are limited, several chemicals have been identified as potential modulators of bitter taste receptors, indirectly influencing T2R38-mediated cellular responses. PNU-281987, although not a specific T2R38 inhibitor, is a bitter taste receptor antagonist that may impact T2R38 signaling indirectly. It can alter bitter taste perception, potentially affecting downstream events associated with T2R38 activation. Similarly, diphenidol, clotrimazole, and procainamide have been reported to inhibit bitter taste receptors, and their influence on T2R38 signaling arises from their general impact on taste perception. Denatonium benzoate and saccharin, known bittering agents, activate bitter taste receptors, including those possibly linked to T2R38. Their activation induces bitter taste signaling cascades, leading to indirect modulation of T2R38-mediated cellular responses. Cycloheximide, denatonium saccharide, bitertanol, and disulfiram are additional compounds influencing bitter taste receptors, and their potential modulation of T2R38 arises from their broader impact on bitter taste perception. Amitriptyline, associated with bitter taste perception, may also indirectly influence T2R38-mediated cellular responses. In summary, while direct T2R38 inhibitors are limited, a diverse array of chemicals can indirectly modulate T2R38 signaling by targeting bitter taste receptors. These compounds provide insights into the complex regulatory networks governing bitter taste perception and its potential implications for taste-related cellular responses. Understanding these indirect modulations opens avenues for further exploration of the interplay between bitter taste receptors and cellular processes influenced by T2R38.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PNU-282,987

123464-89-1sc-200187
sc-200187A
10 mg
50 mg
$170.00
$576.00
3
(1)

PNU-282,987 is a bitter taste receptor antagonist that may indirectly modulate T2R38 signaling. While not a specific T2R38 inhibitor, it can affect bitter taste perception and may impact downstream signaling events related to T2R38 activation, influencing taste-related cellular responses.

Diphenidol hydrochloride

3254-89-5sc-351726
1 g
$59.00
2
(1)

Diphenidol has been shown to inhibit bitter taste receptors. While its exact mechanism on T2R38 is not well-defined, its general bitter taste receptor inhibition may indirectly affect T2R38-mediated responses by interfering with the activation or signaling of these taste receptors.

Clotrimazole

23593-75-1sc-3583
sc-3583A
100 mg
1 g
$41.00
$56.00
6
(2)

Clotrimazole has been suggested to influence bitter taste receptors. Although its specific impact on T2R38 is not fully elucidated, it may indirectly modulate T2R38 signaling by affecting bitter taste perception and associated cellular responses.

Denatonium benzoate

3734-33-6sc-234525
sc-234525A
sc-234525B
sc-234525C
sc-234525D
1 g
5 g
25 g
100 g
250 g
$31.00
$46.00
$138.00
$464.00
$903.00
(1)

Denatonium benzoate is a bittering agent that activates bitter taste receptors. Its role is to induce bitter taste, and its impact on T2R38 may lead to indirect modulation of T2R38-mediated cellular responses by initiating bitter taste signaling cascades.

Terbinafine

91161-71-6sc-338609
100 mg
$560.00
1
(0)

Terbinafine has been associated with bitter taste perception. While the specific interaction with T2R38 is not clearly defined, its potential to modulate bitter taste receptors may indirectly affect T2R38 signaling and associated cellular responses.

Saccharin

81-07-2sc-212902
sc-212902A
sc-212902B
100 mg
1 g
10 g
$173.00
$235.00
$286.00
(0)

Saccharin is an artificial sweetener that activates bitter taste receptors. Its activation of bitter taste receptors, including those possibly related to T2R38, may lead to indirect modulation of T2R38-mediated cellular responses, influencing taste-related signaling pathways.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Cycloheximide, a protein synthesis inhibitor, has been reported to influence bitter taste receptors. While its specific impact on T2R38 is not well-delineated, its general inhibition of bitter taste receptors may indirectly modulate T2R38 signaling and related cellular responses.

Denatonium saccharide

90823-38-4sc-214864
sc-214864A
sc-214864B
1 g
25 g
100 g
$56.00
$106.00
$320.00
(0)

Denatonium saccharide is a bittering agent activating bitter taste receptors. Its impact on T2R38 may induce bitter taste signaling cascades, leading to indirect modulation of T2R38-mediated cellular responses.

Bitertanol

55179-31-2sc-234101
250 mg
$40.00
1
(0)

Bitertanol, a fungicide has been associated with bitter taste perception. Although its specific interaction with T2R38 is not well-characterized, its potential to modulate bitter taste receptors may indirectly influence T2R38 signaling and related cellular responses.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$52.00
$87.00
7
(1)

Disulfiram has been suggested to modulate bitter taste receptors. While its specific impact on T2R38 is not fully understood, its general influence on bitter taste perception may indirectly affect T2R38-mediated cellular responses by altering taste-related signaling pathways.