Synip Activators
Synip activators belong to a class of chemical compounds designed to modulate the activity of Synip (Syntaxin-Interacting Protein), also known as JIP4 (JNK Interacting Protein 4). Synip is a critical regulatory protein in intracellular signaling pathways and vesicle trafficking within cells. It plays a pivotal role in mediating the interaction between vesicle-associated membrane proteins (VAMPs) and syntaxin proteins, essential components of the cellular machinery responsible for vesicle fusion during processes like neurotransmitter release, insulin secretion, and intracellular transport.
Synip activators are specifically engineered to interact with Synip and influence its ability to mediate vesicle fusion events. By targeting Synip, these compounds may modulate the interactions between VAMPs and syntaxins, thereby impacting vesicle trafficking and membrane fusion processes in cells. Research on Synip activators provides valuable insights into the complex mechanisms governing intracellular transport and vesicular release events, offering a deeper understanding of cellular physiology and the regulation of various cellular functions that rely on vesicle trafficking. Understanding the molecular interactions between Synip and its activators is crucial for deciphering the intricate processes that underlie essential cellular functions and intracellular communication. Further investigation is necessary to elucidate the precise mechanisms of action and biological consequences associated with Synip activation, contributing to our knowledge of cell biology and intracellular transport processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin signaling can enhance glucose uptake by translocating GLUT4, which may involve Synip expression changes. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin activates AMPK, which can influence glucose uptake and might affect Synip expression in metabolic tissues. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
As a PPARγ agonist, rosiglitazone affects glucose metabolism and might upregulate Synip expression to improve insulin sensitivity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Another PPARγ agonist, pioglitazone could increase Synip expression, contributing to its insulin-sensitizing actions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase and increases cAMP, which may influence insulin signaling and Synip expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone can affect glucose metabolism and may alter Synip expression in insulin-responsive cells. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine affects glucose metabolism and insulin action, potentially influencing Synip expression during stress responses. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression and differentiation and might influence Synip expression in metabolic tissues. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
Leptin regulates energy balance and may affect glucose uptake and Synip expression in insulin-sensitive tissues. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $112.00 $280.00 | 2 | |
Palmitate is a free fatty acid that induces insulin resistance; it might alter Synip expression as part of its effect on insulin signaling. | ||||||