Syncoilin Activators
Syncoilin activators primarily include molecules that enhance its protein-protein interactions and compounds that modulate enzyme activity to regulate Syncoilin's phosphorylation status. Biocytin, a molecule that enhances protein-protein interactions, increases Syncoilin's functional activity indirectly by augmenting its interactions with desmin and dystrophin. These interactions are vital for Syncoilin's role in cytoskeletal organization. Moreover, Forskolin and IBMX, which increase cAMP levels in cells, promote Syncoilin activity. They achieve this by stimulating protein kinase A (PKA), which can phosphorylate and activate Syncoilin, thereby facilitating its involvement in cytoskeletal organization.
Several Syncoilin activators aim to maintain its active, phosphorylated state by inhibiting the action of protein phosphatases, which are responsible for dephosphorylation. Okadaic acid and Calyculin A, inhibitors of protein phosphatases 1 and 2A, enhance Syncoilin's activity by preventing its dephosphorylation. H-89, a potent and selective inhibitor of PKA, and Cyclosporin A, an inhibitor of calcineurin, similarly work to maintain the phosphorylated, active state of Syncoilin. Additionally, compounds such as Anisomycin, which triggers the stress-activated protein kinase (SAPK)/JNK pathway, and Rapamycin, an inhibitor of mTOR, can potentially enhance Syncoilin's functional activity if Syncoilin is a downstream target of these pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases the levels of cyclic AMP in cells. cAMP can enhance protein kinase A (PKA) activity, which in turn can phosphorylate and activate Syncoilin, leading to an increase in its function in cytoskeletal organization. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cyclic AMP and cyclic GMP in cells. Elevated levels of these molecules can enhance the activity of PKA which can phosphorylate and activate Syncoilin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). If PKC is involved in phosphorylating Syncoilin, activation of PKC by PMA can increase the activity of Syncoilin in the cytoskeletal organization process. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can prevent the dephosphorylation of Syncoilin, thereby maintaining its active state and enhancing its role in cytoskeletal organization. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic acid, Calyculin A is an inhibitor of protein phosphatases 1 and 2A. It can prevent the dephosphorylation of Syncoilin, thereby maintaining its active state and enhancing its functional activity in cytoskeletal organization. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinase (SAPK)/JNK pathway. If Syncoilin is a downstream target of this pathway, anisomycin can enhance the functional activity of Syncoilin in the cytoskeletal organization process. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that activates PKA. Increased PKA activity can lead to the phosphorylation and activation of Syncoilin, thereby enhancing its functional activity in cytoskeletal organization. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. If PKC is involved in phosphorylating Syncoilin, inhibition of PKC by Staurosporine can increase the activity of Syncoilin in the cytoskeletal organization process. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an inhibitor of calcineurin, a phosphatase that can dephosphorylate Syncoilin. By inhibiting calcineurin, it can prevent the dephosphorylation of Syncoilin, thereby maintaining its active state and enhancing its role in cytoskeletal organization. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a kinase that can phosphorylate Syncoilin. By inhibiting mTOR, it can prevent the dephosphorylation of Syncoilin, thereby maintaining its active state and enhancing its role in cytoskeletal organization. | ||||||