SULT2B10 Inhibitors
Chemical inhibitors of SULT2B10 encompass a range of compounds that directly impede the enzyme's sulfonation activity. Triclosan, for instance, can bind to the sulfotransferase domain of SULT2B10, which prevents the necessary binding of endogenous substrates for sulfonation, leading to inhibition. Similarly, Bisphenol A, by interacting with the active site of the enzyme, obstructs the natural substrates from binding, thus inhibiting the enzyme's function. Compounds like Quercetin, Chrysin, and Apigenin serve as competitive inhibitors; they occupy the active site of SULT2B10, thereby preventing the sulfonation of the intended substrates. This competition ensures that the enzyme's activity is reduced as these molecules mimic the structure of the natural substrates to varying degrees, leading to a decrease in the sulfonation function of SULT2B10.
Further inclusion of Kaempferol, Resveratrol, and Ellagic Acid adds to the spectrum of chemical inhibitors by binding to the same active site, each reducing the ability of SULT2B10 to catalyze the transfer of sulfate groups to its substrates. Genistein, Biochanin A, and Naringenin also inhibit SULT2B10 by competing with natural substrates, thus impeding the normal sulfotransferase activity. Curcumin, with its distinct molecular structure, can also bind to the active site of SULT2B10, which obstructs the access of endogenous substrates and inhibits the enzyme's functionality. Each of these chemicals, through their interaction with the active site and competition with endogenous substrates, ensures that the sulfonation activity - vital to the function of SULT2B10 - is effectively inhibited.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan can inhibit SULT2B10 by binding to the sulfotransferase domain of the enzyme, preventing the binding of the endogenous substrates thus directly inhibiting its sulfonation activity. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, a known endocrine disruptor, interacts with the SULT2B10 active site, which can lead to inhibition of the enzyme's function by obstructing the binding of the natural substrates required for sulfonation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can competitively inhibit SULT2B10 by occupying its active site, which blocks the enzyme's ability to catalyze the transfer of sulfate groups to its natural substrates. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin can inhibit SULT2B10 activity by binding to the enzyme's active site, which hinders the binding and sulfonation of endogenous substrates. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin can act as a competitive inhibitor of SULT2B10, occupying the active site and thereby reducing the enzyme's sulfonation activity on its natural substrates. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol can inhibit the activity of SULT2B10 by competing with endogenous substrates for binding to the active site of the enzyme, which decreases its sulfonation function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can inhibit SULT2B10 by directly interacting with the enzyme's active site, preventing the binding and subsequent sulfonation of the endogenous substrates. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic Acid is capable of inhibiting SULT2B10 by binding to its active site, which blocks the enzyme's capacity to sulfonate its natural substrates. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can inhibit SULT2B10 by competing with the natural substrates for binding at the enzyme's active site, thereby impeding its normal sulfotransferase activity. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $77.00 $132.00 | ||
Biochanin A can inhibit the function of SULT2B10 by occupying the binding site of the enzyme, which prevents the sulfonation of its natural substrates. | ||||||