STOML2 Inhibitors
STOML2 inhibitors represent a distinctive chemical class renowned for their intricate involvement in the modulation of essential cellular processes. These inhibitors are meticulously crafted to interact with precision and selectivity with STOML2, an integral protein revered for its multifaceted engagement in a wide array of cellular functions. STOML2, a distinguished member of the stomatin protein family, is ubiquitously expressed across diverse cell types and tissues, prominently localizing within the cell membrane. Notably, its significance lies in its orchestration of intricate regulatory mechanisms pertaining to ion channels, lipid homeostasis, and diverse cellular activities crucial for cellular integrity. The inhibitors that fall within the purview of STOML2 inhibitors exhibit a unique and discerning molecular architecture that endows them with the capability to selectively bind to STOML2. Through this intricate binding process, they garner the capacity to influence, modulate, or perturb the functional intricacies governed by STOML2 within the cellular milieu. The design, synthesis, and refinement of STOML2 inhibitors necessitate an in-depth comprehension of the three-dimensional conformation of the protein, alongside its dynamic interactions with a plethora of cellular constituents.
The paramount significance of STOML2 inhibitors lies in their potential to unravel the cryptic intricacies of cellular mechanisms governed by the protein. As they delicately interfere with STOML2-mediated processes, these inhibitors unfurl a pathway to scrutinize the molecular nuances governing diverse physiological phenomena within cells. The synthesis of STOML2 inhibitors embodies a meticulous fusion of organic synthesis, computational modeling, and structural biology to forge compounds tailored to precisely engage with STOML2's intricate architecture. Ultimately, the realm of STOML2 inhibitors illuminates novel avenues for deciphering the complex web of cellular operations orchestrated by STOML2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
STOML2 activation occurs through stabilization of the mitochondrial membrane potential; Cyclosporin A inhibits mitochondrial permeability transition pore opening, which can stabilize the mitochondrial membrane potential, thereby maintaining STOML2 in an activated state associated with this membrane stabilization. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine stabilizes the cell membrane and can interact with various ion channels to stabilize membrane potential; this stabilization could support STOML2 in maintaining its activated conformation as it is associated with mitochondrial and plasma membrane stability. | ||||||
Nicorandil | 65141-46-0 | sc-200995 sc-200995B sc-200995A sc-200995C | 50 mg 100 mg 250 mg 1 g | $57.00 $98.00 $240.00 $500.00 | 4 | |
Nicorandil opens ATP-sensitive potassium channels, which leads to membrane hyperpolarization; this action can support STOML2 activation as it may maintain the mitochondrial integrity and function where STOML2 is active. | ||||||
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
Diazoxide opens ATP-sensitive potassium channels, similar to Nicorandil; promoting hyperpolarization and potentially enhancing STOML2 activation by preserving mitochondrial function. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
4-Aminopyridine blocks voltage-gated potassium channels, thereby prolonging action potentials; prolonged action potentials may enhance calcium influx indirectly supporting STOML2 activation through increased mitochondrial calcium levels. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvate enhances mitochondrial metabolism and supports ATP production; increased ATP can stabilize mitochondrial function, which is necessary for STOML2's activation and its role in mitochondrial dynamics. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Melatonin is involved in the regulation of mitochondrial homeostasis; it can lead to the preservation of mitochondrial function, thereby potentially enhancing STOML2 activation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions have been shown to influence mitochondrial function; they may contribute to supporting STOML2 activation by stabilizing mitochondria where STOML2 operates. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol supports mitochondrial function and can trigger responses leading to enhanced mitochondrial biogenesis; this action can support STOML2 activation due to its mitochondrial association. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Methylene Blue assists in the maintenance of mitochondrial electron transport chain function; this support of the electron transport chain can help maintain proper mitochondrial function, which is necessary for STOML2 activation. | ||||||