STAG3 Activators
STAG3 Activators are a class of chemical compounds designed to enhance the functional activity of the cohesin complex protein STAG3. STAG3 is a critical component of the cohesin ring structure that ensures proper chromosome segregation during meiosis, and its activators play a pivotal role in modulating the chromosomal architecture necessary for this process. These activators can increase the affinity of STAG3 for sister chromatids, thereby strengthening the cohesin complex's grip and ensuring accurate chromosome alignment and segregation. STAG3 activators achieve this by stabilizing the protein's structure or enhancing its interaction with other cohesin components such as SMC1, SMC3, and RAD21. Some of the activators may work by influencing post-translational modifications of the STAG3 protein, which are crucial for its function in meiosis. By augmenting the stability and function of STAG3 within the cohesin complex, these activators ensure that the intricate process of genetic recombination and segregation during gamete formation is carried out with high fidelity.
Furthermore, the activators of STAG3 can indirectly boost the protein's activity by modulating the cellular pathways that regulate cohesin's assembly and maintenance on the chromosomes. They might enhance the ATPase activity of the cohesin complex or affect the regulatory factors that control cohesin's loading and unloading from DNA. For example, certain activators might prevent premature separation of sister chromatids by inhibiting separase, the enzyme responsible for cleaving cohesin, thereby indirectly amplifying STAG3's role in maintaining chromosomal cohesion. Others could influence the phosphorylation state of cohesin's components, a post-translational modification that is essential for the function of STAG3 during meiosis. By ensuring the precise timing and location of cohesin's action, STAG3 activators are crucial for the integrity of the genetic information passed on to the next generation. Through these specific molecular mechanisms, STAG3 activators are integral to the proper execution of meiotic cell division, without directly influencing gene expression or protein synthesis pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to promote the stabilization and proper functioning of cohesin complexes, of which STAG3 is a critical component. It enhances the interaction between cohesin subunits, thereby supporting the role of STAG3 in chromosomal segregation during meiosis. | ||||||
NOC-18 | 146724-94-9 | sc-202247 sc-202247A sc-202247B sc-202247C | 10 mg 50 mg 100 mg 500 mg | $50.00 $180.00 $299.00 $1100.00 | 18 | |
Nitric oxide donors release nitric oxide which can modulate the function of various proteins through S-nitrosylation. S-nitrosylation of cohesin complex proteins may enhance their stability or interaction with chromatin, which would indirectly enhance STAG3 function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can increase acetylation levels of cohesin complex proteins, leading to enhanced chromatin association. This could indirectly increase STAG3's function by promoting its chromosomal binding activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium impacts Wnt signaling pathway, which has been implicated in gene expression regulation during development. Through enhancing Wnt signaling, lithium could promote the expression of genes encoding cohesin complex components, including STAG3. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor which can prevent the degradation of cohesin complex proteins, potentially increasing the levels of STAG3 and enhancing its function in the cell. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
Calpeptin is a calpain inhibitor. Inhibition of calpain, which is involved in the cleavage of various cellular proteins, may indirectly lead to the stabilization of cohesin complex proteins and the enhancement of STAG3 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase leading to an increase in cAMP levels which can enhance protein interactions within the cohesin complex, possibly supporting STAG3's functional activity in cellular processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator, and AMPK activation has been linked to various cellular stabilization processes which could include cohesin complex proteins, thereby potentially enhancing the activity of STAG3. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist, which can influence the transcription of various genes. It may enhance the function of STAG3 by upregulating the expression of genes encoding for cohesin complex components. | ||||||