Smo Activators
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $56.00 $180.00 | 18 | |
An agonist of the Hedgehog signaling pathway that directly binds to SMO, potentially influencing its expression or activity. | ||||||
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $206.00 $510.00 | 31 | |
A chlorobenzothiophene-containing compound that activates the Hedgehog pathway by binding to SMO. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $163.00 $413.00 | 27 | |
SAG functions as a potent Smo inhibitor, characterized by its ability to disrupt the hedgehog signaling pathway. Its unique molecular architecture facilitates strong binding to the Smo receptor, leading to conformational changes that hinder downstream signaling. The compound exhibits distinct hydrophobic interactions, enhancing its affinity for the target site. Additionally, its kinetic profile reveals a rapid onset of action, making it an effective modulator of cellular signaling cascades. | ||||||
SAG Analog (trans-isomer) | sc-396539 | 1 mg | $195.00 | |||
SAG Analog (trans-isomer) acts as a selective Smo antagonist, showcasing a unique ability to stabilize the inactive conformation of the Smo protein. Its structural features promote specific electrostatic interactions with key residues, effectively blocking ligand-induced activation. The compound's distinct lipophilicity enhances membrane permeability, while its reaction kinetics indicate a prolonged engagement with the target, allowing for sustained modulation of signaling pathways. | ||||||
SAG Analog (cis-isomer) | 1401532-77-1 | sc-396546 | 1 mg | $195.00 | ||
SAG Analog (cis-isomer) exhibits a unique mechanism as a Smo modulator, characterized by its ability to induce a conformational shift in the Smo protein. This isomer engages in specific hydrophobic interactions that differ from its trans counterpart, influencing the dynamics of receptor activation. Its distinct steric properties facilitate selective binding, while the compound's reactivity as an acid halide allows for versatile modifications, enhancing its potential for tailored interactions within cellular pathways. | ||||||
GSA 10 | 300833-95-8 | sc-397041 sc-397041A | 10 mg 50 mg | $131.00 $739.00 | ||
GSA 10 functions as a Smo modulator through its distinctive ability to stabilize the active conformation of the Smo protein. This compound showcases unique electrostatic interactions that promote enhanced receptor affinity, differentiating it from other modulators. Its reactivity as an acid halide enables the formation of covalent bonds with nucleophilic sites, leading to altered signaling pathways. Additionally, GSA 10's specific steric configuration contributes to its selective engagement with downstream effectors, influencing cellular responses. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
A selective SMO antagonist. Its effect on SMO expression requires further investigation. | ||||||
20α-Hydroxy Cholesterol | 516-72-3 | sc-209393 | 10 mg | $300.00 | ||
Endogenous modulators of the Hedgehog pathway that can bind to and activate SMO. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
A GLI inhibitor that targets the Hedgehog pathway downstream of SMO. Its presence might indirectly influence SMO expression. | ||||||
RU-SKI 43 | 1043797-53-0 | sc-507508 | 5 mg | $395.00 | ||
A small molecule that inhibits Hedgehog signaling, potentially impacting SMO expression or activity. | ||||||