SMC5 Activators
SMC5 activators encompass a diverse range of chemical compounds that indirectly enhance the functional activity of SMC5, predominantly through their influence on various cellular signaling pathways and stress responses. Resveratrol and Nicotinamide Mononucleotide elevate SIRT1 function and NAD+ levels, respectively, which are crucial for the deacetylation and consequent activation of DNA repair proteins such as SMC5. Similarly, Trichostatin A, by inhibiting histone deacetylases, improves the recruitment of SMC5 to chromatin, thereby facilitating its role in chromosomal stabilization. AICAR and Palbociclib function through the activation of AMPK and inhibition of CDK4/6, respectively, leading to a cellular environment that promotes the activation of SMC5 during energy stress or cell cycle arrest. Chloroquine's inhibition of autophagy and VE-821's ATR inhibition, as well as Olaparib's PARP inhibition, create a cellular state with increased DNA damage, compelling the cell to enhance the role of SMC5 in DNA repair and maintenance.
The continued activity of SMC5 in cellular stress responses is further supported by chemicals like Nocodazole and Pipecolic Acid. Nocodazole, by interrupting microtubule dynamics, indirectly necessitates the upregulation of DNA repair mechanisms, including SMC5's role during cell cycle checkpoints. Pipecolic Acid's induction of heat shock proteins potentially ensures the stabilization and proper function of SMC5 under stress conditions. Meanwhile, Mirin's inhibition of the MRN complex redirects DNA repair reliance towards SMC5-mediated pathways. Lastly, SP600125's inhibition of the JNK signaling pathway may shift the balance of cellular DNA repair strategies, enhancing the utilization of SMC5 for maintaining genomic integrity. Collectively, these activators underscore the multifaceted regulation of SMC5, illustrating the protein's critical involvement in cell cycle progression, DNA repair, and the response to cellular stressors.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates the SIRT1 signaling pathway. SIRT1, in turn, is known to regulate proteins involved in DNA repair and maintenance, such as SMC5, by deacetylating these proteins and thus enhancing their activity in chromosomal cohesion and DNA damage repair processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that alters chromatin structure and accessibility. By inhibiting histone deacetylases, Trichostatin A can enhance the access of SMC5 to chromatin, indirectly promoting its role in DNA repair and chromosomal stabilization. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK) which is implicated in cellular energy homeostasis. Activation of AMPK has been associated with the phosphorylation and subsequent activation of proteins involved in DNA damage response, potentially including SMC5. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
β-Nicotinamide mononucleotide is a precursor of NAD+, which is a substrate for sirtuins. By increasing NAD+ levels, NMN can enhance SIRT1 activity, which may indirectly enhance the function of SMC5 in DNA repair mechanisms. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine indirectly enhances DNA repair mechanisms by inhibiting DNA damage-induced autophagy. This can lead to a compensatory upregulation of DNA repair proteins, potentially including SMC5, as the cell attempts to maintain genomic integrity. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is an ATR inhibitor that sensitizes cells to DNA damage by inhibiting the ATR-mediated DNA damage response. This can lead to an increased reliance on alternative DNA repair mechanisms, potentially enhancing the activity of SMC5 in maintaining chromosomal stability. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor that traps PARP on DNA breaks, leading to the accumulation of DNA damage. This can indirectly enhance the activity of SMC5, as part of the cellular compensatory mechanisms to deal with increased DNA damage and promote genomic stability. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization leading to cell cycle arrest. During this arrest, the cell enhances DNA repair processes to prepare for mitosis, potentially increasing the activity of SMC5 in its role of maintaining chromosomal integrity during cell division. | ||||||