SHISA9 Activators
SHISA9, also known as CKAMP44, is a transmembrane protein predominantly expressed in the brain, particularly in the hippocampus and cortex. Functionally, SHISA9 plays a crucial role in regulating synaptic transmission and plasticity, thereby influencing cognitive functions such as learning and memory. Structurally, SHISA9 contains a signal peptide for membrane insertion, a highly conserved C-terminal PDZ-binding motif, and an N-terminal domain interacting with AMPA receptors (AMPARs). Through its interaction with AMPARs, SHISA9 modulates their trafficking, gating properties, and synaptic localization, ultimately impacting synaptic strength and plasticity. Moreover, SHISA9 is implicated in the regulation of excitatory synaptic transmission and long-term potentiation (LTP), processes crucial for synaptic plasticity and memory formation.
Activation of SHISA9 involves various mechanisms aimed at enhancing its interaction with AMPA receptors and promoting its synaptic localization. One such mechanism involves the phosphorylation of specific residues within SHISA9 by protein kinases such as PKA and PKC, which can facilitate its interaction with AMPARs and potentiate synaptic transmission. Additionally, interactions with scaffolding proteins such as PSD-95 and GRIP1 may stabilize SHISA9-AMPA receptor complexes at synapses, leading to increased synaptic strength and plasticity. Furthermore, activity-dependent mechanisms such as neuronal depolarization and synaptic stimulation can trigger the translocation of SHISA9 to synaptic sites, where it can exert its modulatory effects on AMPAR function. Overall, the activation of SHISA9 represents a crucial regulatory mechanism in synaptic plasticity and cognitive processes, highlighting its significance in neural circuit function and behavior.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PKA. PKA phosphorylation can enhance SHISA9 function by modulating its interactions with other proteins or its localization within the synapse. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), preventing the breakdown of cAMP. Elevated cAMP levels can activate PKA, which may then potentiate SHISA9 activity by phosphorylation or altering its synaptic localization. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels. This elevation can activate PKA, which in turn could enhance the activity of SHISA9 through phosphorylation that affects its function in synaptic plasticity. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin is a non-competitive antagonist of GABA(A) receptors. By inhibiting inhibitory neurotransmission, it can indirectly enhance excitatory synaptic activity, potentially increasing the functional demand on SHISA9 in excitatory synapses. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $208.00 | 2 | |
CNQX is an AMPA receptor antagonist that, through homeostatic synaptic scaling, might lead to compensatory upregulation of postsynaptic function, indirectly enhancing SHISA9 activity in response to reduced excitatory input. | ||||||
Aniracetam | 72432-10-1 | sc-203514 sc-203514A | 50 mg 250 mg | $115.00 $456.00 | ||
Aniracetam is a positive allosteric modulator of AMPA receptors. It can enhance excitatory synaptic transmission, which may upregulate SHISA9 function in synaptic plasticity to modulate the strength of excitatory synapses. | ||||||
Cyclothiazide | 2259-96-3 | sc-202560 sc-202560A | 10 mg 50 mg | $107.00 $227.00 | 3 | |
Cyclothiazide acts as a positive allosteric modulator of AMPA receptors by preventing desensitization. This enhancement of excitatory synaptic transmission could indirectly increase the functional requirements for SHISA9 at synapses. | ||||||
Tianeptine | 66981-73-5 | sc-213044 sc-213044A | 10 mg 50 mg | $250.00 $422.00 | ||
Tianeptine increases the uptake of serotonin (5-HT), and the resultant changes in serotonergic signaling could enhance synaptic plasticity mechanisms that involve SHISA9, thus potentially increasing its functional activity at synapses. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $82.00 $281.00 | ||
(+)-Bicuculline is a competitive antagonist of GABA(A) receptors. By blocking inhibitory synaptic transmission, it can indirectly increase excitatory neurotransmission, possibly leading to enhanced SHISA9 function in the context of synaptic plasticity. | ||||||