Date published: 2025-12-9

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Shf Activators

Shf Activators are an exclusive class of chemical compounds that specifically interact with and increase the functionality of the Shf protein through a variety of unique molecular mechanisms. These activators are crafted to leverage the innate biochemical pathways that Shf is involved in, ensuring that their interactions lead to a pronounced augmentation of Shf's activity within cellular processes. For instance, certain activators within this class may target the phosphorylation sites on Shf, promoting an increase in its phosphorylation status, which is a common post-translational modification that Shf undergoes to become fully active. The precise nature of these activators allows them to bind selectively to Shf or its immediate modulators, enhancing the protein's ability to participate in its native signaling cascades. Such cascades are integral to the proper functioning of the cells, particularly in pathways where Shf is known to play a pivotal role, such as signal transduction, cellular growth, and proliferation.

Moreover, the chemical architecture of Shf Activators is such that it might facilitate the interaction of Shf with other molecular partners within the cell, thereby boosting its activity. These activators could induce conformational changes in Shf or its partners, thus favoring the formation of active complexes or the recruitment of additional effector molecules that propagate the signaling events Shf is associated with. The activation process is highly specific to the structural and functional nuances of Shf, ensuring that the upregulation of its activity is a direct consequence of the activators' actions, rather than an indiscriminate enhancement of various proteins. This specificity is crucial in maintaining cellular homeostasis and function, as it ensures that the activation of Shf is a controlled and targeted event, not interfering with other cellular mechanisms or pathways. The activators are thus key in fine-tuning the cellular processes that rely on Shf's activity, providing a precise tool to enhance the protein's function where it is naturally designed to operate.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate Shf, enhancing its activity in intracellular signaling.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. The rise in calcium can activate calcium-dependent kinases, which may phosphorylate Shf and enhance its signaling activity.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can lead to the phosphorylation and activation of Shf through downstream signaling cascades.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

Sphingosine-1-phosphate (S1P) interacts with its G-protein-coupled receptors, initiating signaling cascades that can result in the activation of Shf via kinase-mediated pathways.

FTY720

162359-56-0sc-202161
sc-202161A
sc-202161B
1 mg
5 mg
25 mg
$32.00
$75.00
$118.00
14
(1)

FTY720 is phosphorylated in vivo to form FTY720-phosphate, which can mimic S1P and activate S1P receptors, potentially enhancing Shf signaling through similar mechanisms as S1P.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187 is a calcium ionophore that increases intracellular calcium levels, which can lead to the activation of Shf by stimulating calcium-sensitive signaling pathways.

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$45.00
$130.00
$480.00
$4450.00
74
(7)

Dibutyryl-cAMP is a cell-permeable analog of cAMP that activates PKA. PKA-mediated phosphorylation can activate Shf by enhancing its interaction with other signaling proteins.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

Epigallocatechin gallate (EGCG) acts as an antioxidant and has been found to modulate various signaling pathways, potentially leading to the activation of Shf through indirect effects on kinases and phosphatases.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a rise in cytosolic calcium levels which may activate Shf through calcium-dependent signaling pathways.