Shf Activators are an exclusive class of chemical compounds that specifically interact with and increase the functionality of the Shf protein through a variety of unique molecular mechanisms. These activators are crafted to leverage the innate biochemical pathways that Shf is involved in, ensuring that their interactions lead to a pronounced augmentation of Shf's activity within cellular processes. For instance, certain activators within this class may target the phosphorylation sites on Shf, promoting an increase in its phosphorylation status, which is a common post-translational modification that Shf undergoes to become fully active. The precise nature of these activators allows them to bind selectively to Shf or its immediate modulators, enhancing the protein's ability to participate in its native signaling cascades. Such cascades are integral to the proper functioning of the cells, particularly in pathways where Shf is known to play a pivotal role, such as signal transduction, cellular growth, and proliferation.
Moreover, the chemical architecture of Shf Activators is such that it might facilitate the interaction of Shf with other molecular partners within the cell, thereby boosting its activity. These activators could induce conformational changes in Shf or its partners, thus favoring the formation of active complexes or the recruitment of additional effector molecules that propagate the signaling events Shf is associated with. The activation process is highly specific to the structural and functional nuances of Shf, ensuring that the upregulation of its activity is a direct consequence of the activators' actions, rather than an indiscriminate enhancement of various proteins. This specificity is crucial in maintaining cellular homeostasis and function, as it ensures that the activation of Shf is a controlled and targeted event, not interfering with other cellular mechanisms or pathways. The activators are thus key in fine-tuning the cellular processes that rely on Shf's activity, providing a precise tool to enhance the protein's function where it is naturally designed to operate.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate Shf, enhancing its activity in intracellular signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. The rise in calcium can activate calcium-dependent kinases, which may phosphorylate Shf and enhance its signaling activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can lead to the phosphorylation and activation of Shf through downstream signaling cascades. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) interacts with its G-protein-coupled receptors, initiating signaling cascades that can result in the activation of Shf via kinase-mediated pathways. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 is phosphorylated in vivo to form FTY720-phosphate, which can mimic S1P and activate S1P receptors, potentially enhancing Shf signaling through similar mechanisms as S1P. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can lead to the activation of Shf by stimulating calcium-sensitive signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP that activates PKA. PKA-mediated phosphorylation can activate Shf by enhancing its interaction with other signaling proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) acts as an antioxidant and has been found to modulate various signaling pathways, potentially leading to the activation of Shf through indirect effects on kinases and phosphatases. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a rise in cytosolic calcium levels which may activate Shf through calcium-dependent signaling pathways. | ||||||