SFXN5 Inhibitors
Chemical inhibitors of SFXN5 can impede its function in several ways, primarily by disrupting the mitochondrial environment or the iron transport pathways that are crucial for its activity. Antimycin A, Oligomycin, Thenoyltrifluoroacetone (TTFA), and Rotenone are inhibitors that target different complexes of the mitochondrial electron transport chain. Antimycin A, by inhibiting complex III, disrupts the mitochondrial membrane potential, which is necessary for SFXN5's role in mitochondrial iron transport. Oligomycin blocks ATP synthase, thereby diminishing the energy supply required for SFXN5's function. TTFA, as a complex II inhibitor, and Rotenone, a complex I inhibitor, contribute to the reduction of mitochondrial function, which can lead to an indirect decrease in SFXN5 activity, due to its association with mitochondrial metabolism.
Deferoxamine, Ciclopirox, and Tetrathiomolybdate are iron chelators that sequester iron, thereby limiting its availability for transport by SFXN5. Deferoxamine and Tetrathiomolybdate, by reducing free iron levels, can inhibit the iron transport function of SFXN5 within mitochondria. Ciclopirox also has similar iron-chelating effects, which can lead to an indirect inhibition of SFXN5. Additionally, Mitoquinone mesylate, by modulating mitochondrial oxidative stress, can alter the redox state within mitochondria and can thus affect the functioning of SFXN5 related to iron handling. Iodoacetate, by interfering with glycolysis, can lead to a decrease in ATP levels, which is necessary for SFXN5's energy-dependent iron transport. Auranofin, by inhibiting thioredoxin reductase, alters cellular redox homeostasis, which can indirectly affect SFXN5's mitochondrial function. Lastly, inhibitors like KCN and Sodium azide directly inhibit mitochondrial complex IV, leading to a cessation of electron transport and a subsequent decrease in ATP production, which can result in an inhibition of SFXN5's role in iron metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits the mitochondrial electron transport chain at complex III. By impeding electron flow, it can decrease the mitochondrial membrane potential, affecting iron transport and thereby possibly inhibiting SFXN5 function related to iron transport within mitochondria. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits mitochondrial ATP synthase, which could reduce ATP production and indirectly affect the energy-dependent processes in which SFXN5 is involved, including iron transport within mitochondria. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) is an inhibitor of the mitochondrial respiratory chain complex II. Inhibition of complex II can lead to reduced mitochondrial function and indirectly impair SFXN5's role in mitochondrial metabolism. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
Deferoxamine is an iron chelator that sequesters free iron. By decreasing available iron, it can indirectly inhibit SFXN5's function in iron transport, as SFXN5 is implicated in mitochondrial iron homeostasis. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
Mitoquinone mesylate is a mitochondria-targeted antioxidant that can modulate mitochondrial oxidative stress. By altering the redox state within mitochondria, it could indirectly inhibit SFXN5 by affecting the mitochondrial environment and iron handling. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
Ciclopirox is a synthetic antifungal agent with iron chelating properties. By chelating iron, it could indirectly inhibit SFXN5's role in mitochondrial iron transport. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $56.00 $97.00 | ||
Iodoacetate is an inhibitor of glycolysis that alkylates cysteine residues in enzymes like glyceraldehyde-3-phosphate dehydrogenase. By disrupting glycolysis, it can decrease cellular ATP levels, potentially inhibiting energy-dependent functions of SFXN5. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin is a gold-containing compound that inhibits thioredoxin reductase, which can lead to altered redox homeostasis in cells. This alteration can affect mitochondrial function and indirectly inhibit SFXN5's role in iron metabolism. | ||||||
Ammonium tetrathiomolybdate | 15060-55-6 | sc-239242 sc-239242A sc-239242B sc-239242C | 1 g 10 g 25 g 50 g | $46.00 $199.00 $413.00 $515.00 | ||
Tetrathiomolybdate is a copper chelator that also exhibits secondary iron chelation properties. By chelating iron, it could indirectly inhibit SFXN5's role in mitochondrial iron transport. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. Inhibition of complex I can lead to a decrease in mitochondrial electron transport and ATP production, potentially impacting SFXN5's role in mitochondrial iron handling. | ||||||