SerpinB1a Inhibitors
SerpinB1a inhibitors are compounds that target and modulate the activity of SerpinB1a, a member of the serine protease inhibitor (serpin) superfamily. Serpins are large, complex proteins that play critical roles in controlling proteolytic pathways by inhibiting specific serine proteases. SerpinB1a is an intracellular, non-classical serpin that primarily regulates neutrophil elastase and other proteases within the serine family. Neutrophil elastase is a proteolytic enzyme involved in breaking down proteins and other components within cells, making SerpinB1a essential for maintaining cellular protease homeostasis. The inhibition of SerpinB1a disrupts its normal regulatory function, leading to an increase in protease activity. This interaction between inhibitors and SerpinB1a has significant implications for understanding the biochemical processes that rely on protease balance, including cell differentiation, apoptosis, and tissue remodeling.
From a biochemical perspective, SerpinB1a inhibitors can have diverse structures, ranging from small molecules to peptide-based compounds, and they can exhibit high specificity for their target. The binding of an inhibitor to SerpinB1a typically alters its conformational state, impacting its ability to inhibit protease targets efficiently. These inhibitors may bind to either the active site of SerpinB1a or allosteric regions, leading to a structural change that affects its inhibitory capacity. Investigating the interaction of these inhibitors with SerpinB1a is crucial for elucidating the mechanisms of protease regulation and understanding how serpins control proteolytic activity within various cellular contexts. By studying these inhibitors, researchers gain deeper insights into protein-protein interactions, the structural flexibility of serpins, and the precise regulation of proteolytic networks within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may directly bind to promoter regions of specific genes, potentially leading to the suppression of transcriptional activity of the SERPINB1 gene, resulting in lower SerpinB1a protein synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has the capability to downregulate pro-inflammatory signaling pathways, which could include the suppression of SerpinB1a expression as part of a broader anti-inflammatory effect. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could inhibit the initiation of transcription for a number of genes involved in inflammatory responses, which might encompass the gene coding for SerpinB1a, thus reducing its expression levels. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin may cause the acetylation of specific transcription factors, potentially leading to the decreased initiation of the SERPINB1 gene transcription and, subsequently, SerpinB1a protein levels. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate can lead to hyperacetylation of histones at gene promoters, which in some cases results in transcriptional repression; this process might decrease SerpinB1a expression if applied to its gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can bind to retinoic acid receptors, leading to altered transcription of genes involved in cell differentiation and apoptosis, possibly including a downregulation of the SERPINB1 gene. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate may lead to a decrease in nucleotide synthesis, limiting the building blocks for gene transcription and potentially resulting in reduced levels of SerpinB1a. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea reduces the pool of deoxyribonucleotides, which could lead to a decrease in DNA replication fidelity and a subsequent reduction in SerpinB1a expression during cell division. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR complex 1, which is crucial for protein synthesis; this inhibition could result in a global decrease in protein levels, including that of SerpinB1a. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can incorporate into DNA and RNA, causing demethylation of DNA and interference with methyltransferase activity, potentially leading to the repression of SERPINB1 gene expression. | ||||||