Septin 11 Inhibitors
Septins are a family of GTP-binding proteins that play critical roles in various cellular processes, including cell division, membrane remodeling, and cytoskeletal organization. These filament-forming proteins are essential for maintaining cell shape, intracellular compartmentalization, and coordination of membrane dynamics. Septins assemble into higher-order structures, forming filaments, rings, or arrays that act as scaffolds for organizing cellular components. Their signaling function involves regulating membrane curvature, vesicle trafficking, and cell polarization. Septins also interact with various proteins and directly influence membrane architecture, making them central to cellular morphogenesis and membrane dynamics.
The significance of septin 11 (SEPT11) inhibitors lies in their potential to modulate the activity of SEPT11, a member of the septin protein family. By targeting septin assembly and function, inhibitors can impact cell division, migration, and signaling pathways. Understanding septin biology and developing inhibitors can provide insights into addressing various diseases, including cancer, neurodegenerative disorders, and infections.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubules, which could affect SEPT11 by altering its interaction with cytoskeletal elements. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin and prevents its polymerization. Septin 11 interacts with the cytoskeleton, which is composed of actin filaments. By disrupting actin polymerization, Latrunculin A could inhibit Septin 11 by disrupting its cytoskeletal associations necessary for its function. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A sequesters actin dimers and prevents their polymerization. Given Septin 11's association with the actin cytoskeleton, the prevention of actin polymerization could inhibit the proper function of Septin 11 by disturbing its cytoskeletal interactions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation. This action can inhibit Septin 11 by disrupting the actin cytoskeleton to which Septin 11 is functionally connected. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can also induce actin polymerization. This stabilization can inhibit Septin 11's functionality by altering the dynamics of the actin cytoskeleton that Septin 11 relies on for proper localization and activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. This action could inhibit Septin 11 by altering microtubule dynamics and thus affecting Septin 11's interactions with microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin, disrupting microtubule assembly. As Septin 11 interacts with microtubules, Vinblastine could inhibit Septin 11 by preventing its proper association with microtubules. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $205.00 $405.00 | 9 | |
Nilotinib is a tyrosine kinase inhibitor. Although primarily used for its action on BCR-ABL, tyrosine kinases play a role in various signaling pathways, including those regulating cytoskeletal dynamics. Nilotinib could inhibit Septin 11 by altering signaling pathways that regulate cytoskeletal elements that Septin 11 interacts with. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, which regulates actin cytoskeleton organization. By inhibiting ROCK, Y-27632 could inhibit Septin 11 by preventing proper cytoskeletal reorganization needed for Septin 11's cellular functions. | ||||||