Septin 11 抑制因子

Septins are a family of GTP-binding proteins that play critical roles in various cellular processes, including cell division, membrane remodeling, and cytoskeletal organization. These filament-forming proteins are essential for maintaining cell shape, intracellular compartmentalization, and coordination of membrane dynamics. Septins assemble into higher-order structures, forming filaments, rings, or arrays that act as scaffolds for organizing cellular components. Their signaling function involves regulating membrane curvature, vesicle trafficking, and cell polarization. Septins also interact with various proteins and directly influence membrane architecture, making them central to cellular morphogenesis and membrane dynamics.

The significance of septin 11 (SEPT11) inhibitors lies in their potential to modulate the activity of SEPT11, a member of the septin protein family. By targeting septin assembly and function, inhibitors can impact cell division, migration, and signaling pathways. Understanding septin biology and developing inhibitors can provide insights into addressing various diseases, including cancer, neurodegenerative disorders, and infections.