sEH Activators
The class of chemicals known as sEH Activators comprises compounds that can either directly or indirectly enhance the activity of soluble epoxide hydrolase (sEH), an enzyme responsible for the metabolism of epoxyeicosatrienoic acids (EETs). EETs are bioactive lipid molecules involved in various cellular processes, and their regulation plays a crucial role in maintaining physiological homeostasis. These sEH activators can influence sEH activity by different mechanisms. Indirect activators like oleic acid, resveratrol, and Fenofibrate can upregulate sEH expression through nuclear receptor activation, leading to increased sEH levels. This indirect effect indirectly influences EET metabolism and cellular processes governed by EETs.
The intricate interplay of sEH activators and their diverse mechanisms highlights the significance of sEH in cellular regulation. These compounds showcase how the modulation of sEH activity can impact the levels of EETs, which, in turn, participate in various signaling pathways and processes essential for maintaining cellular homeostasis. Understanding the mechanisms by which sEH activators function can shed light on the intricate lipid metabolism and cellular processes that govern physiological responses in various tissues and organs, providing insights into the broader implications of sEH modulation in biological systems.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is an indirect activator of sEH. It stimulates sEH expression by activating peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor involved in lipid metabolism. This activation leads to increased sEH levels, indirectly impacting EET metabolism and cellular processes influenced by EETs. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is an indirect activator of sEH. It activates sEH expression through its interaction with sirtuin 1 (SIRT1), a protein deacetylase that regulates cellular processes. By increasing sEH levels via SIRT1 activation, resveratrol indirectly influences the metabolism of epoxyeicosatrienoic acids (EETs), which play a role in various cellular pathways and processes. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is an indirect activator of sEH. It serves as a substrate for sEH, promoting its activity by providing more epoxyeicosatrienoic acids (EETs) to metabolize. The increased availability of EETs due to arachidonic acid metabolism indirectly affects cellular processes regulated by EETs. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
PPARα agonists, like fenofibrate, indirectly activate sEH by upregulating its expression through activation of the PPARα nuclear receptor. This increase in sEH levels indirectly influences the metabolism of epoxyeicosatrienoic acids (EETs) and cellular processes regulated by EETs. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid is an indirect activator of sEH. It serves as a substrate for sEH, promoting its activity by providing more epoxyeicosatrienoic acids (EETs) to metabolize. The increased availability of EETs due to linoleic acid metabolism indirectly affects cellular processes regulated by EETs. | ||||||
2-Ethylhexyl diphenyl phosphate | 1241-94-7 | sc-225350 | 25 g | $42.00 | ||
2-Ethylhexyl diphenyl phosphate indirectly enhances the levels of epoxyeicosatrienoic acids (EETs). This inhibition indirectly affects cellular processes regulated by EETs. | ||||||