Sec61β Activators
The class of chemicals considered as potential Sec61β activators comprises a diverse group primarily influencing the endoplasmic reticulum (ER) environment, protein folding processes, and associated stress responses. Given the lack of direct activators for Sec61β, these chemicals are selected for their ability to modulate the cellular milieu, which may indirectly affect the functionality of the Sec61 complex. Their mechanisms of action vary from disrupting ER calcium homeostasis, inhibiting specific protein processing steps, to affecting overall protein trafficking and folding within the ER.
Sec61β, as a part of the Sec61 translocon, is critical in co-translational translocation of proteins into the ER. Chemicals like Tunicamycin and Thapsigargin indirectly impact Sec61β by inducing ER stress and activating the unfolded protein response (UPR), a key regulatory system that manages ER protein load and functionality. Agents such as Dithiothreitol (DTT) and 4-Phenylbutyrate (4-PBA) influence protein folding environments, which can alter the demands and dynamics of protein translocation through the Sec61 complex. Other compounds like Brefeldin A and MG132 affect ER-Golgi trafficking and proteasome function, respectively, thereby influencing ER-associated degradation (ERAD) processes and potentially impacting Sec61β function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, stressing the ER and potentially influencing Sec61β activity indirectly through unfolded protein response (UPR) activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
This compound disrupts calcium homeostasis in the ER, indirectly affecting Sec61β by activating the UPR and altering ER functions. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts ER-Golgi trafficking, potentially influencing Sec61β activity by altering ER membrane dynamics and protein trafficking. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
A chemical chaperone that eases ER stress, potentially affecting Sec61β by modulating protein folding and translocation processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that leads to protein accumulation in the ER, potentially influencing Sec61β activity through increased demand for ER-associated degradation (ERAD). | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
This ionophore disrupts calcium balance, potentially affecting Sec61β by altering ER functions and stress responses. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
An ionophore that disrupts mitochondrial function, potentially influencing Sec61β indirectly through cellular stress responses. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
An Hsp90 inhibitor that can cause protein misfolding in the ER, potentially influencing Sec61β activity through enhanced UPR. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Inhibits calcineurin, potentially affecting Sec61β indirectly by altering cellular stress responses and calcium signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, potentially influencing Sec61β activity by modulating cellular growth pathways and protein synthesis. | ||||||