Date published: 2026-3-10

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S-100P Inhibitors

S-100P inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of S-100P, a member of the S100 family of calcium-binding proteins that are involved in various intracellular and extracellular regulatory activities. S-100P, like other S100 proteins, plays a crucial role in modulating cellular processes such as proliferation, differentiation, apoptosis, and cytoskeletal dynamics. It functions by interacting with target proteins in a calcium-dependent manner, influencing their activity, stability, and localization within the cell. S-100P is known to be involved in the regulation of several signaling pathways, including those related to cell growth and survival, making it an important factor in maintaining cellular homeostasis. By inhibiting S-100P, researchers can disrupt these regulatory processes, offering a tool to study the specific contributions of S-100P to cellular signaling and function.

In research settings, S-100P inhibitors are valuable tools for exploring the molecular mechanisms by which S-100P influences cellular behavior and the broader implications of calcium-binding proteins on cellular regulation. By blocking the activity of S-100P, scientists can investigate how the inhibition affects the interaction between S-100P and its target proteins, particularly focusing on the downstream effects on signaling pathways that control cell proliferation, cytoskeletal organization, and cell motility. This inhibition allows researchers to study the impact on cellular processes such as migration, invasion, and response to environmental stimuli, where S-100P plays a significant role. Additionally, S-100P inhibitors provide insights into the interactions between S-100P and other S100 family members, shedding light on the complex networks that regulate cellular functions and the maintenance of cellular integrity. Through these studies, the use of S-100P inhibitors enhances our understanding of the critical role of calcium-binding proteins in cellular physiology, the regulation of signaling pathways, and the broader implications of S-100P activity in various biological contexts.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BAPTA/AM

126150-97-8sc-202488
sc-202488A
25 mg
100 mg
$138.00
$458.00
61
(2)

Chelates intracellular calcium, potentially disrupting S-100P mediated signaling pathways.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), indirectly affecting S-100P activity.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$28.00
$53.00
37
(1)

Modulates intracellular calcium release, potentially interfering with S-100P functions.

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$59.00
$173.00
15
(1)

Blocks calcium channels, potentially altering calcium-dependent processes involving S-100P.

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Inhibits L-type calcium channels, which could indirectly affect S-100P related signaling.

Dantrolene

7261-97-4sc-500165
25 mg
$350.00
7
(0)

Inhibits ryanodine receptors, potentially disrupting S-100P associated calcium signaling.

TMB-8 • HCl

53464-72-5sc-3522
sc-3522A
10 mg
50 mg
$43.00
$129.00
10
(1)

Inhibits intracellular calcium release, potentially affecting S-100P mediated pathways.

Nimodipine

66085-59-4sc-201464
sc-201464A
100 mg
1 g
$61.00
$307.00
2
(1)

Blocks voltage-gated calcium channels, potentially influencing S-100P related activities.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
50 g
100 g
250 g
1 kg
5 kg
$33.00
$67.00
$97.00
$192.00
$775.00
13
(1)

Releases intracellular calcium stores, potentially modulating S-100P functions.

Amlodipine

88150-42-9sc-200195
sc-200195A
100 mg
1 g
$74.00
$166.00
2
(1)

Inhibits calcium channels, potentially affecting pathways involving S-100P.