RTEL1 Activators
The chemical class RTEL1 Activators encompasses a diverse range of compounds, primarily antioxidants and polyphenols, that can indirectly influence the activity of RTEL1. These chemicals do not directly activate RTEL1 but modulate various cellular pathways and processes that are integral to DNA repair and telomere maintenance, in which RTEL1 plays a key role.
The primary action of these chemicals involves modulation of oxidative stress, DNA repair pathways, and the expression of enzymes and proteins related to DNA maintenance. For instance, compounds like Epigallocatechin gallate (EGCG) and Curcumin influence the ATM/ATR signaling pathway and base excision repair pathway, respectively. Such modulation can have a downstream effect on the activity of RTEL1, as these pathways are crucial for the cellular processes in which RTEL1 is involved. Similarly, Resveratrol's activation of SIRT1, a protein that plays a role in DNA repair, presents another mechanism through which RTEL1 activity can be indirectly influenced. Additionally, the role of minerals like Zinc and Selenium is noteworthy. These elements are essential for the proper functioning of numerous enzymes involved in DNA synthesis and repair. Their presence in optimal amounts is crucial for maintaining the integrity of DNA repair mechanisms, thereby indirectly affecting the activity of RTEL1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea, EGCG modulates DNA repair pathways. It influences the ATM/ATR signaling pathway, which is crucial for DNA repair. This modulation can indirectly affect RTEL1's role in DNA repair. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A polyphenol in turmeric, Curcumin alters the expression of DNA repair enzymes. It influences pathways like base excision repair, potentially affecting RTEL1's function in telomere maintenance indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A stilbenoid found in grapes, Resveratrol activates SIRT1, a protein deacetylase that modulates DNA repair mechanisms. This activation can indirectly influence RTEL1's function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonol present in many fruits, Quercetin modulates oxidative stress response pathways. This modulation can indirectly influence RTEL1's activity in DNA repair and telomere maintenance. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, Sulforaphane affects the Nrf2 pathway, which is involved in cellular response to oxidative stress. This might indirectly influence RTEL1's role in DNA repair. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
As an antioxidant, Vitamin C modulates oxidative stress and can influence pathways involved in DNA repair, potentially affecting RTEL1. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
An antioxidant, N-Acetyl-L-cysteine influences glutathione levels and oxidative stress response, which could indirectly modulate RTEL1's activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
An essential mineral, Zinc is crucial for DNA synthesis and repair. Its presence can influence RTEL1 activity by modulating DNA repair pathways. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
An essential mineral, Selenium is involved in antioxidant defense systems and can influence DNA repair mechanisms, potentially affecting RTEL1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A soy isoflavone, Genistein influences several signaling pathways including those involved in DNA repair, potentially affecting RTEL1's activity. | ||||||