rotavirus vp7 Inhibitors
Chemical inhibitors of rotavirus VP7 can interfere with the protein's function through various mechanisms. Lumefantrine operates by disrupting heme polymerization, a process that shares similarities with the stability needed by VP7 for its function during virus assembly. Interruption of such processes can destabilize VP7. Glycyrrhizin, known for its ability to hinder viral attachment and penetration, can disrupt VP7's role in cell attachment and entry. Castanospermine and Deoxynojirimycin, both glucosidase inhibitors, can prevent the proper folding and glycosylation of VP7, which is crucial for its maturation and function. This disruption leads to the production of misfolded and non-functional VP7 proteins.
Ribavirin, a nucleoside analogue, can lead to the synthesis of defective VP7 by acting as a mutagen for viral RNA. Cytarabine, although primarily used for its action against DNA polymerase, can extend its mechanism to RNA-dependent RNA polymerase, thereby producing defective VP7 proteins. Amantadine disrupts proton channels, which can trap VP7 within an uncoated viral particle, inhibiting its role in virus assembly. Sulfasalazine's inhibition of NF-κB can decrease the efficiency of VP7 in viral assembly and immune evasion by reducing the inflammatory response that facilitates rotavirus replication. Curcumin's interference with cellular pathways can disrupt the correct folding and assembly of VP7. Disulfiram, by inhibiting proteases, can prevent the proper cleavage and maturation of VP7. Niclosamide's uncoupling of phosphorylation can limit the energy available for VP7 function during viral replication. Lastly, suramin's ability to block enzyme activities and receptor interactions can prevent VP7 from binding to host cells, which is essential for viral attachment and entry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine is a glucosidase inhibitor that disrupts the folding and maturation of viral glycoproteins. VP7 is a glycoprotein that undergoes glycosylation; hence, castanospermine could prevent its proper folding and maturation, leading to functional inhibition. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin is another glucosidase inhibitor, which would similarly inhibit the maturation of the rotavirus VP7 glycoprotein by preventing its proper glycosylation, resulting in misfolded proteins that are functionally inactive. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a nucleoside analogue that can inhibit the replication of RNA viruses. While it primarily acts as a mutagen for viral RNA, its incorporation could lead to synthesis of defective rotavirus VP7, resulting in non-functional proteins. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a cytidine analog that inhibits DNA polymerase. While it is used against certain types of cancer, the mechanism of action includes interference with nucleotide incorporation which could extend to RNA-dependent RNA polymerase, leading to the production of defective rotavirus VP7. | ||||||
1-Adamantylamine | 768-94-5 | sc-251475 sc-251475A | 1 g 25 g | $39.00 $147.00 | ||
Amantadine disrupts proton channels and thereby inhibits the uncoating of viruses. This mechanism can cause the rotavirus VP7 to be trapped within an uncoated viral particle, inhibiting its function in the assembly and pathogenesis of the virus. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine inhibits NF-κB, a transcription factor involved in the inflammatory response. Since inflammatory responses can facilitate rotavirus replication and VP7 function, its inhibition may reduce the efficiency of VP7-mediated viral assembly and immune evasion. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin interferes with a variety of molecular targets and has been reported to inhibit the replication of certain viruses. It may interfere with the rotavirus VP7 by disrupting cellular pathways necessary for the correct folding and assembly of this protein. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit proteases and other enzymes. By interfering with proteolytic processing, it could potentially prevent the proper cleavage required for VP7 maturation, leading to the production of non-functional VP7 proteins. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide uncouples phosphorylation in mitochondria, leading to energy depletion. As viral replication and protein function such as that of VP7 are energy-dependent, niclosamide could indirectly inhibit VP7 function by limiting the energy available for viral replication. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin inhibits a variety of enzymes and may block the interaction between viral proteins and cellular receptors. By blocking receptor interactions, suramin could prevent rotavirus VP7 from binding to host cells, thereby inhibiting its function in viral attachment and entry. | ||||||