reticulocalbin-3 Inhibitors
The chemical class of reticulocalbin-3 (RCN3) inhibitors constitutes a diverse assembly of compounds meticulously designed to intricately modulate calcium homeostasis and endoplasmic reticulum (ER) function. RCN3, a member of the reticulocalbin family, plays a pivotal role in calcium binding and contributes to ER-associated processes, including protein folding and calcium-mediated signaling cascades. Thapsigargin, a prominent member of this class, disrupts sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps, crucial components in calcium transport across the ER membrane. This disruption results in perturbations in calcium dynamics, indirectly impacting RCN3 and its regulatory functions within the ER. Tunicamycin, another inhibitor within this chemical class, exerts its influence by disrupting N-glycosylation processes, thus influencing protein folding. This perturbation contributes to the stability of RCN3 within the ER environment, unveiling a nuanced mechanism of action.
Calcium chelators such as BAPTA-AM and EGTA, along with ionophores like A23187, further amplify the diversity of this chemical class. These compounds play pivotal roles in altering intracellular calcium levels, intricately influencing RCN3-mediated signaling cascades. Dantrolene, through its action of reducing calcium release, intricately impacts processes related to RCN3 and adds another layer to the intricate network of modulators within this chemical class. Additionally, inhibitors like Ruthenium Red, 2-APB, and Neomycin act on different components of calcium channels and phosphoinositide pathways, providing a multifaceted approach to indirectly affect RCN3. Wortmannin, a phosphoinositide 3-kinase (PI3-kinase) inhibitor, disrupts phosphoinositide signaling pathways, revealing another facet of the chemical class's capabilities. Xestospongin C and U73122 target inositol trisphosphate (IP3) receptor-mediated calcium release and phospholipase C, respectively, further expanding the repertoire of mechanisms by which this chemical class influences RCN3-related processes. Collectively, these inhibitors form a comprehensive toolkit for researchers, offering intricate insights into the nuanced involvement of RCN3 in calcium-related signaling pathways within the endoplasmic reticulum.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits SERCA pumps, disrupting calcium homeostasis. This indirectly influences reticulocalbin-3 (RCN3) as it binds calcium and is implicated in calcium signaling. Altered calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disturbance in calcium dynamics due to Thapsigargin can lead to changes in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-glycosylation, affecting protein folding in the endoplasmic reticulum (ER). As RCN3 is an ER-resident protein involved in calcium homeostasis, disrupting glycosylation with Tunicamycin indirectly influences RCN3. Altered protein folding dynamics in the ER can impact RCN3's stability and function, potentially modulating its involvement in calcium signaling pathways. The disturbance in glycosylation processes can lead to changes in RCN3-mediated cellular responses associated with ER function and calcium homeostasis. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that sequesters intracellular calcium. By disrupting calcium signaling, it indirectly influences RCN3, a calcium-binding protein. Changes in intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disturbance in calcium dynamics due to BAPTA-AM can lead to alterations in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
EGTA is a cell-impermeable calcium chelator that binds extracellular calcium. By disrupting extracellular calcium availability, it indirectly influences RCN3, a calcium-binding protein. Changes in extracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disturbance in calcium dynamics due to EGTA can lead to alterations in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that facilitates calcium transport across membranes. By promoting calcium influx, it indirectly influences RCN3, a calcium-binding protein. Increased intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The elevation in calcium dynamics due to A23187 can lead to alterations in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits the ryanodine receptor, reducing calcium release from the sarcoplasmic reticulum. By impacting calcium dynamics, it indirectly influences RCN3, a calcium-binding protein. Altered intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The reduction in calcium release due to Dantrolene can lead to changes in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red inhibits various calcium channels. By interfering with calcium entry, it indirectly influences RCN3, a calcium-binding protein. Changes in intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disruption in calcium dynamics due to Ruthenium Red can lead to alterations in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) inhibits IP3 receptor-mediated calcium release. By modulating calcium signaling, it indirectly influences RCN3, a calcium-binding protein. Altered intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disruption in calcium dynamics due to 2-APB can lead to changes in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $26.00 $34.00 | 20 | |
Neomycin is an aminoglycoside antibiotic that disrupts phosphoinositide metabolism, affecting calcium signaling. By modulating phosphoinositide pathways, it indirectly influences RCN3, a calcium-binding protein. Changes in intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disturbance in phosphoinositide metabolism due to Neomycin can lead to alterations in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3-kinases, affecting phosphoinositide signaling. By disrupting phosphoinositide pathways, it indirectly influences RCN3, a calcium-binding protein. Changes in intracellular calcium levels impact RCN3's function in calcium binding and potential interactions with other cellular components. The disturbance in phosphoinositide metabolism due to Wortmannin can lead to alterations in RCN3-mediated processes, modulating its role in calcium-related signaling pathways within the endoplasmic reticulum. | ||||||