RBM34 Inhibitors
RBM34 inhibitors are a class of chemical compounds designed to target and inhibit the function of RBM34, an RNA-binding protein that plays an important role in regulating post-transcriptional gene expression. RBM34 belongs to the RNA-binding motif (RBM) protein family, which is known for influencing RNA metabolism, including mRNA splicing, stability, transport, and translation. Specifically, RBM34 contains RNA recognition motifs (RRMs) that allow it to bind to specific RNA sequences, thus regulating the processing and maturation of mRNA. This regulation is crucial for ensuring that RNA transcripts are properly processed and translated into functional proteins, which are essential for various cellular functions such as growth, differentiation, and adaptation to environmental changes. RBM34 inhibitors function by binding to critical regions of the protein, such as its RNA-binding domains, thereby blocking its ability to interact with RNA and interfering with its regulatory roles in RNA processing.
The inhibition of RBM34 can result in disruptions to the normal post-transcriptional processes it governs, leading to altered splicing patterns, mRNA stability, and translation. By preventing RBM34 from executing its RNA-binding functions, these inhibitors affect the generation of specific protein isoforms that are necessary for the proper functioning of cells. Researchers use RBM34 inhibitors to explore the specific contributions of this protein in the regulation of mRNA and to gain insights into how it affects broader gene expression networks within cells. These inhibitors also help scientists understand the complex interactions between RNA-binding proteins and other components of the cellular machinery involved in RNA metabolism. Additionally, RBM34 inhibitors provide valuable insights into the mechanisms by which RNA-binding proteins control gene expression at the post-transcriptional level, offering a deeper understanding of how cells fine-tune their proteome in response to various physiological demands and developmental signals.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits the export of RNA-binding proteins from the nucleus by binding to Exportin 1 (CRM1), leading to the accumulation of RNA-binding motif protein 34 in the nucleus and its functional inhibition due to improper cellular localization. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Pladienolide B binds to the spliceosome, disrupting the splicing machinery where RNA-binding motif protein 34 is involved. This disruption hinders proper mRNA processing, thereby inhibiting the function of RNA-binding motif protein 34. | ||||||
FR901464 | 146478-72-0 | sc-507352 | 5 mg | $1800.00 | ||
FR901464 targets the spliceosome, preventing the proper assembly and function of this complex, which is critical for the role of RNA-binding motif protein 34 in RNA splicing, leading to its inhibition. | ||||||
Madrasin | 374913-63-0 | sc-507563 | 100 mg | $750.00 | ||
Madrasin selectively inhibits splicing by targeting the SF3b complex, crucial for the splicing process in which RNA-binding motif protein 34 operates, therefore inhibiting its function. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Spliceostatin A acts as a potent spliceosome inhibitor, binding to the SF3b complex and disrupting its interaction with the pre-mRNA, which is essential for RNA-binding motif protein 34 activity, resulting in its inhibition. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene, also known as GEX1A, targets the spliceosome and alters splicing by binding to the SF3b complex, thus inhibiting the splicing activity that involves RNA-binding motif protein 34. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Thioguanine is incorporated into RNA as a guanine analogue, which can disrupt RNA metabolism and processing, thereby inhibiting the function of RNA-binding proteins like RNA-binding motif protein 34 by causing incorrect RNA folding and function. | ||||||