RASL11A Activators
RASL11A, a member of the Ras superfamily of small GTPases, plays a crucial role in diverse cellular processes by acting as a molecular switch that regulates signaling cascades involved in cell growth, proliferation, and differentiation. Despite sharing structural features with classical Ras proteins, RASL11A exhibits distinct functional properties and signaling mechanisms. The activation of RASL11A is primarily mediated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP, thereby promoting the transition of RASL11A from an inactive GDP-bound state to an active GTP-bound state. Once activated, GTP-bound RASL11A interacts with downstream effector molecules, such as kinases and adaptor proteins, to propagate intracellular signaling events that govern various cellular responses.
The activation of RASL11A is intricately regulated by upstream signaling pathways, including receptor-mediated activation of GEFs and modulation of RASL11A protein expression levels. Growth factor receptors, such as receptor tyrosine kinases (RTKs), can stimulate RASL11A activation by recruiting specific GEFs to the plasma membrane, where they catalyze the exchange of nucleotides on RASL11A. Additionally, post-translational modifications, such as phosphorylation and ubiquitination, can modulate the activity and stability of RASL11A, further influencing its activation state. Furthermore, the spatial and temporal dynamics of RASL11A activation are finely tuned by regulatory mechanisms that control the localization and availability of GEFs and GTPase-activating proteins (GAPs), which promote the hydrolysis of GTP to GDP, thus inactivating RASL11A. Overall, elucidating the precise mechanisms governing RASL11A activation provides valuable insights into its physiological functions and its potential contributions to various cellular processes and disease states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP). Elevated cAMP levels activate protein kinase A (PKA), which can phosphorylate and activate RASL11A. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, triggering the activation of G proteins and subsequent activation of adenylate cyclase. This results in increased cAMP levels, which can activate protein kinase A (PKA) to phosphorylate and activate RASL11A. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
L-Glutamic Acid binds to ionotropic glutamate receptors, leading to depolarization of the cell membrane and activation of calcium influx. Increased intracellular calcium levels can activate calmodulin-dependent kinases, which in turn activate RASL11A. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to insulin receptors, activating the insulin receptor tyrosine kinase and initiating downstream signaling cascades. These pathways can activate RASL11A through phosphorylation events mediated by various kinases, including PI3K and MAPK. | ||||||
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $260.00 $1040.00 | 1 | |
Vasopressin binds to vasopressin receptors, leading to activation of phospholipase C (PLC) and generation of inositol trisphosphate (IP3). IP3 triggers calcium release from intracellular stores, leading to activation of calmodulin-dependent kinases and subsequent activation of RASL11A. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to dopamine receptors, activating adenylate cyclase through G protein-mediated signaling. Increased cAMP levels activate protein kinase A (PKA), which can phosphorylate and activate RASL11A. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Also called Serotonin, this compound binds to serotonin receptors, leading to activation of adenylate cyclase through G protein-mediated signaling. Elevated cAMP levels activate protein kinase A (PKA), which can phosphorylate and activate RASL11A. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to histamine receptors, leading to activation of adenylate cyclase through G protein-mediated signaling. Increased cAMP levels activate protein kinase A (PKA), which can phosphorylate and activate RASL11A. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine binds to adrenergic receptors, triggering the activation of G proteins and subsequent activation of adenylate cyclase. This results in increased cAMP levels, which can activate protein kinase A (PKA) to phosphorylate and activate RASL11A. | ||||||
Thyrotropin-Releasing Hormone | 24305-27-9 | sc-481830A sc-481830 sc-481830B sc-481830C | 10 mg 50 mg 100 mg 250 mg | $86.00 $156.00 $284.00 $664.00 | ||
TRH binds to thyrotropin-releasing hormone receptors, activating phospholipase C (PLC) and inducing the production of inositol trisphosphate (IP3). IP3 triggers calcium release from intracellular stores, leading to activation of calmodulin-dependent kinases and subsequent activation of RASL11A. | ||||||