R-cadherin Inhibitors
R-cadherin inhibitors are a class of chemical compounds designed to modulate the activity of R-cadherin, a specific subtype of cadherin proteins. Cadherins are a family of cell adhesion molecules that play a fundamental role in mediating cell-cell adhesion and tissue organization. R-cadherin, also known as retinal cadherin or cadherin-4, is a subtype of cadherin primarily found in the nervous system, including the retina and the brain. It plays a critical role in neural development, specifically in guiding axonal pathfinding and synaptic connectivity during neurogenesis.
The primary function of R-cadherin inhibitors is to interfere with the adhesive properties of R-cadherin molecules, thereby influencing cell-cell interactions in neural tissues. These inhibitors can be small organic molecules or peptides designed to bind to R-cadherin and disrupt its adhesive interactions. By doing so, they can potentially impact processes like neuronal migration, axonal guidance, and synapse formation, which are essential for the establishment of neural circuits. Researchers have been exploring the use of R-cadherin inhibitors as valuable tools for studying neural development and plasticity in experimental settings. Understanding the mechanisms underlying R-cadherin-mediated adhesion can shed light on the intricacies of neural circuit formation, which has implications for fields like neuroscience and developmental biology. These inhibitors, by selectively targeting R-cadherin, allow scientists to dissect the specific contributions of this cadherin subtype in neural development, offering insights into the broader picture of brain development and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, which may lead to demethylation of gene promoter regions and alter gene expression. Reduction in DNA methylation at the R-cadherin gene promoter could potentially inhibit its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This is a histone deacetylase inhibitor that can modulate chromatin structure and influence gene expression. By altering the acetylation state of histones, Trichostatin A may reduce the transcriptional activity of the R-cadherin gene, thereby inhibiting its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
As a histone deacetylase inhibitor, Vorinostat can change chromatin dynamics and affect gene expression. Its action on the chromatin may lead to reduced expression of R-cadherin by modifying the transcriptional activity of its gene. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As an antimetabolite, 5-Fluorouracil can be incorporated into RNA and DNA, disrupting normal cellular functions. This disruption can lead to altered gene expression patterns, potentially including the inhibition of R-cadherin expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, affecting nucleotide synthesis and cellular replication. These disruptions can result in changes to gene expression, possibly including the downregulation of R-cadherin. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
This platinum-based chemotherapeutic agent forms DNA adducts, leading to DNA damage and alterations in gene expression. These alterations might include the inhibition of R-cadherin expression as the cell responds to DNA damage. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway, which is involved in cell growth and proliferation. Inhibition of this pathway can lead to altered gene expression patterns, including potential downregulation of R-cadherin. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis. This disruption can lead to changes in gene expression, potentially including a decrease in R-cadherin expression. | ||||||