PWWP2B Activators
PWWP2B Activators encompass a variety of chemical compounds that influence epigenetic modifications and chromatin dynamics, indirectly augmenting PWWP2B's functional activities. Forskolin, by raising cAMP levels, activates PKA, whichcan phosphorylate substrates that may interact with PWWP2B, thereby facilitating its role in chromatin remodeling and gene expression regulation. Similarly, Ionomycin elevates intracellular calcium, which can activate calcium-dependent kinases potentially affecting the phosphorylation state of PWWP2B or its associated proteins, enhancing PWWP2B's activity in epigenetic regulation. Trichostatin A and SAHA, both histone deacetylase inhibitors, promote a more open chromatin structure that could improve PWWP2B's access to chromatin, thus potentiating its regulatory functions. Meanwhile, 5-Azacytidine and RG108, as DNA methyltransferase inhibitors, and S-Adenosylmethionine, a methyl donor, directly impact the methylation landscape PWWP2B interacts with, possibly enhancing its gene expression modulatory role.
Continuing with this theme, Epigallocatechin gallate (EGCG) and Methylcobalamin, by influencing DNA methylation patterns, might augment the interaction of PWWP2B with methylated genomic regions, impacting gene regulation. Anacardic acid's inhibition of histone acetyltransferases can shift the balance of histone modifications, indirectly enhancing PWWP2B's chromatin-associated activities. BIX-01294's inhibition of histone methyltransferases may similarly modify the histone marks that PWWP2B binds, affecting its role in gene expression. Lastly, Parthenolide's modulation of NF-κB signaling provides a broader context for PWWP2B's enhanced activity by potentially altering the gene regulatory environment in which PWWP2B functions, thus indirectly elevating its role in the epigenetic mechanisms that govern gene expression. Together, these PWWP2B Activators, through their targeted impact on signaling pathways and chromatin states, facilitate the enhancement of PWWP2B's involvement in the complex network of epigenetic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in the cell. Elevated cAMP can activate protein kinase A (PKA), which in turn can phosphorylate target proteins, including those that interact with PWWP2B, enhancing its functional activity within the nucleus related to chromatin remodeling and gene expression regulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Calcium signaling can result in the activation of calcium-dependent protein kinases, which might affect PWWP2B by altering its phosphorylation state or the activity of proteins that modulate PWWP2B's function in epigenetic modifications. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By preventing deacetylation, it leads to a more relaxed chromatin structure. This can enhance the accessibility of PWWP2B to chromatin, indirectly enhancing its role in gene expression by facilitating epigenetic modifications. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It reduces DNA methylation, which can lead to chromatin relaxation and potentially increase the ability of PWWP2B to bind methylated DNA, thereby enhancing its regulatory functions in gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) has been shown to influence DNA methylation status. By modifying the methylation landscape, EGCG can potentially enhance the interaction of PWWP2B with methylated regions, affecting its role in gene expression modulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA, like Trichostatin A, is a histone deacetylase inhibitor that leads to a more open chromatin state, potentially facilitating PWWP2B's interaction with chromatin and enhancing its role in the regulation of gene expression patterns. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is another DNA methyltransferase inhibitor that lowers DNA methylation, potentially enhancing the binding efficiency of PWWP2B to methylated histone regions, thus influencing gene expression regulation. | ||||||
Mecobalamin | 13422-55-4 | sc-211781 | 10 mg | $300.00 | ||
Methylcobalamin is a form of vitamin B12 that can act as a cofactor in methylation reactions. Its presence may influence the methylation landscape of DNA and histones, potentially enhancing PWWP2B's role in the recognition and binding to methylated regions, thus affecting gene regulatory functions. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid inhibits histone acetyltransferases, which may alter the balance of histone acetylation and methylation, indirectly affecting the binding and activity of PWWP2B in chromatin modifications and gene expression. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX-01294 is a histone methyltransferase inhibitor that can alter histone methylation patterns. This may indirectly affect the functional activity of PWWP2B by changing the histone marks that PWWP2B recognizes and binds to, thereby modulating its role in gene expression. | ||||||