PRRC1 Activators
Activators of PRRC1 operate through various biochemical mechanisms to increase its functional activity. For instance, some activators work by modulating intracellular second messenger systems, such as cAMP. These compounds elevate cAMP levels, which in turn activate protein kinase A (PKA). Activated PKA can phosphorylate a wide range of substrates, including PRRC1, thereby enhancing its activity. Another group of activators exerts their effects by manipulating intracellular calcium levels. These compounds facilitate the influx of calcium into the cytoplasm, which activates calcium-dependent kinases. These kinases are capable of phosphorylating PRRC1, which leads to its functional activation.
Additional activators of PRRC1 act through various growth factor and hormone signaling pathways that ultimately result in the phosphorylation of PRRC1. For example, certain activators bind to and activate specific receptors, initiating a signaling cascade through the MAPK/ERK or PI3K/Akt pathways, both of which are known to regulate a multitude of cellular functions, including the phosphorylation of numerous proteins. Other activators inhibit the dephosphorylation process, thus maintaining PRRC1 in a phosphorylated and active state. There are also compounds that modulate the activity of enzymes responsible for the post-translational modification of proteins, such as deacetylation, which in turn can influence PRRC1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This adenylate cyclase activator increases intracellular cyclic AMP (cAMP) levels. Elevated cAMP enhances the activity of protein kinase A (PKA), which can phosphorylate PRRC1, leading to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As an activator of protein kinase C (PKC), PMA leads to the phosphorylation of various substrates including PRRC1, thereby increasing its activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
This calcium ionophore elevates intracellular calcium levels, which can activate calcium-dependent kinases that subsequently phosphorylate and activate PRRC1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor signaling activates the PI3K/Akt pathway, which can lead to the phosphorylation and activation of a myriad of proteins, potentially including PRRC1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
This cAMP analog mimics the action of endogenous cAMP by activating PKA, which may phosphorylate and activate PRRC1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, enhancing PKA activity that could phosphorylate and activate PRRC1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
This calcium ionophore raises intracellular calcium concentration, activating calcium-dependent kinases that may target PRRC1 for activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3 leading to increased activity in the Wnt signaling pathway, which could indirectly lead to the activation of PRRC1. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a substrate for sirtuins, NAD+ may enhance the deacetylation of proteins, which can affect the activity of proteins including PRRC1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As a potent inhibitor of protein phosphatases PP1 and PP2A, okadaic acid prevents dephosphorylation, maintaining proteins such as PRRC1 in an activated phosphorylated state. | ||||||