PPP2R3C Activators
PPP2R3C activators function by manipulating the phosphorylation state within the cell, thereby influencing the activity of the protein. For example, certain small molecules can increase intracellular cyclic AMP levels, which in turn activate protein kinase A. The active kinase A then phosphorylates inhibitory proteins that regulate PPP2R3C, which reduces their ability to inhibit this phosphatase, resulting in its activation. Alternatively, some activators work by preventing the degradation of cyclic nucleotides, leading to sustained activation of kinase pathways that ultimately enhance the activity of PPP2R3C. Phosphoprotein phosphatase inhibitors, such as those that target PP1 and PP2A, lead to an overall increase in the phosphorylation levels within the cell. This buildup of phosphorylated substrates can trigger a feedback mechanism, potentially involving PPP2R3C, to restore phosphorylation balance. Moreover, certain inhibitors directly enhance the phosphorylation state of proteins that are known to interact with PPP2R3C, thereby facilitating its activation.
Other mechanisms by which PPP2R3C activators exert their influence include the modulation of protein kinase C, which phosphorylates and activates PPP2R3C or its upstream regulators. Some activators mimic natural ligands, binding to receptors and initiating signaling cascades that result in the activation of PPP2R3C. For instance, lipid signaling pathways can be influenced by activators that change the levels of diacylglycerol (DAG) or phosphatidylinositol bisphosphate (PIP2), both of which are known to activate protein kinase C (PKC).
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Stimulates adenylate cyclase activity, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP levels enhance protein kinase A (PKA) activity which can phosphorylate inhibitor proteins of PPP2R3C, leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-specific inhibitor of phosphodiesterases, it prevents the degradation of cAMP and cGMP, thereby indirectly promoting the activity of PKA which can subsequently activate PPP2R3C by phosphorylating its inhibitory partners. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), can indirectly lead to increased phosphorylation levels in the cell, thereby reducing the inhibitory effects on PPP2R3C and enhancing its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Inhibitor of PP1 and PP2A resulting in increased phosphorylation of proteins, potentially leading to a compensatory activation of PPP2R3C as part of a regulatory feedback mechanism. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Inhibits PP2A and PP1, which may lead to the accumulation of phosphorylated proteins and a subsequent compensatory response involving the activation of PPP2R3C. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $122.00 | 3 | |
Activates protein kinase C (PKC) which can phosphorylate and thereby activate PPP2R3C or its upstream regulators. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A PKC activator which can enhance the phosphorylation of proteins that regulate PPP2R3C activity. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
Can be phosphorylated to act as an agonist, potentially influencing the activity of PPP2R3C through complex lipid signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Disrupts endoplasmic reticulum calcium stores, leading to elevated cytosolic calcium levels that activate calmodulin-dependent kinase II (CaMKII), which could then activate PPP2R3C through downstream effects on phosphorylation status. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Acts as a PP2A inhibitor which could lead to an upregulation of PPP2R3C activity as part of the cell's attempt to maintain protein phosphorylation homeostasis. | ||||||