POLR2C Inhibitors
POLR2C Inhibitors are a category of molecules that target the POLR2C subunit of the RNA polymerase II complex. RNA polymerase II is a crucial enzyme in cellular processes, responsible for transcribing DNA into its corresponding mRNA. This polymerase is composed of various subunits, each playing a specific role in the transcription process. The POLR2C subunit, also known as RPB3, forms an essential component of this complex, facilitating the assembly and stabilization of the core polymerase structure. Inhibitors targeting POLR2C can disrupt the function and assembly of the RNA polymerase II complex, thereby impeding the transcription process.
The precise mechanism of POLR2C inhibitors may vary depending on the specific compound, but in general, they interact with the POLR2C subunit to prevent its normal function. These inhibitors can bind to the POLR2C subunit, either competitively or allosterically, reducing its ability to contribute to the overall polymerase activity. Because the POLR2C subunit plays a critical role in stabilizing the RNA polymerase II complex and ensuring the fidelity of transcription, its inhibition can lead to significant disruptions in gene expression. It's important to note that while these inhibitors have a targeted action on the POLR2C subunit, their effects can be broad-reaching due to the central role of RNA polymerase II in cellular gene expression. Thus, understanding the specific interactions and consequences of POLR2C inhibition can provide insights into the intricate mechanisms of cellular transcription regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A cyclic peptide toxin found in the death cap mushroom (Amanita phalloides). Binds directly to RNA polymerase II, specifically the bridge helix and trigger loop, hindering the elongation phase of transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
A polypeptide antibiotic produced by certain Streptomyces species. Intercalates between guanine-cytosine DNA base pairs, preventing the DNA from serving as a template for RNA synthesis. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
A synthetic compound. Inhibits the positive transcription elongation factor b (P-TEFb), essential for the elongation phase of transcription by RNA polymerase II. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide from the plant Tripterygium wilfordii. Binds directly to the XPB subunit of TFIIH, a component of the RNA polymerase II pre-initiation complex, preventing transcription initiation. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A synthetic flavonoid found in an Indian plant. Blocks phosphorylation of RNA polymerase II, preventing transcription elongation. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $156.00 | 5 | |
A synthetic compound primarily known as a BTK inhibitor. While its primary target is Bruton's tyrosine kinase (BTK), has also been shown to inhibit RNA polymerase II by an unclear mechanism. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
An antibiotic belonging to the rifamycin group. Binds to the β subunit of bacterial RNA polymerase, blocking the RNA synthesis. Effect on eukaryotic RNA polymerase II is less pronounced but can still influence transcription. | ||||||
Cucurbitacin I | 2222-07-3 | sc-203010 | 1 mg | $250.00 | 9 | |
A compound found in certain plants, part of the cucurbitacin family. Affects various cellular signaling pathways, which can indirectly influence transcription. | ||||||