Pol I/II/III RPB8 Activators
Pol I/II/III RPB8 is an essential subunit shared among three major eukaryotic RNA polymerases: RNA polymerase I, II, and III. Each polymerase is responsible for transcribing different types of RNA. RNA polymerase I is primarily involved in the synthesis of ribosomal RNA (rRNA), RNA polymerase II synthesizes messenger RNA (mRNA) as well as some small nuclear RNAs (snRNA), and RNA polymerase III is responsible for the transcription of transfer RNA (tRNA) and other small RNAs. The RPB8 subunit, being a part of all three complexes, plays a crucial role in the transcriptional machinery of the cell. It is integral to the assembly and stability of the RNA polymerases and is vital for their proper function. The expression of RPB8, therefore, is tightly linked to the core process of gene expression and is influenced by a wide array of cellular signals and environmental cues that dictate the need for protein synthesis.
Exploring the biochemical landscape, various chemical activators have been identified that can potentially upregulate the expression of proteins such as Pol I/II/III RPB8. These compounds engage with cellular pathways that govern gene expression, not by targeting RPB8 directly, but by creating conditions that are conducive to the transcription of a broad set of genes. Histone deacetylase inhibitors like Trichostatin A and Sodium Butyrate promote a more open chromatin structure, which can increase accessibility to the DNA for transcription factors and the transcriptional machinery, potentially enhancing the production of RPB8. Compounds such as Forskolin and Retinoic Acid, through their interaction with intracellular signaling cascades, can lead to an increase in transcriptional activity, thereby raising the levels of numerous proteins, including RPB8. Other molecules like Epigallocatechin gallate (EGCG) and Sulforaphane activate cellular defense pathways, which can indirectly stimulate the synthesis of various transcription-related proteins. These activators represent a fraction of the molecular agents that can interact with the sophisticated network of cellular processes to maintain the essential flow of genetic information.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, as a histone deacetylase inhibitor, may promote transcriptional activation by inducing a relaxed chromatin structure that is more accessible for transcription machinery, potentially stimulating RPB8 synthesis. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into nucleic acids, 5-Azacytidine hinders methylation, a process that generally silences gene expression. This can lead to the upregulation of genes, including those coding for essential transcription components like RPB8. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates cAMP levels, which can enhance the transcription of a multitude of genes by activating cAMP-dependent protein kinase A (PKA), possibly leading to an increase in RPB8 levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA directly stimulates protein kinase C, which can initiate a cascade of events culminating in the transcriptional elevation of various genes, including the possible upsurge in RPB8 production. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, by inhibiting histone deacetylase, can induce hyperacetylation which may enhance the transcriptional activity of genes, potentially including the gene encoding RPB8. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid binds to nuclear receptors to initiate transcription, which could lead to the heightened synthesis of proteins, potentially encompassing RPB8. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, which may lead to an upsurge in gene transcription, including the genes responsible for the assembly of transcription machinery such as RPB8. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate has been shown to stimulate antioxidant response pathways, which could lead to the enhanced expression of genes involved in cellular defense, potentially including those related to transcription like RPB8. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane activates the Nrf2 pathway, which can precipitate the transcriptional elevation of cytoprotective genes, and it might extend this stimulatory effect to genes such as that encoding RPB8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been observed to stimulate transcriptional activity through its interaction with various cellular kinases, which could lead to an increase in the production of transcription-related proteins, including RPB8. | ||||||