PNPLA7 Activators

The list of chemicals thought to indirectly activate PNPLA7 primarily focuses on modulating lipid metabolism and signaling pathways. Oleic Acid, for instance, boosts triglyceride synthesis and can activate PNPLA7, as this enzyme plays a role in triglyceride hydrolysis. Fenofibrate acts as a PPARα agonist, promoting fatty acid oxidation. This increased oxidation rate necessitates higher activity of enzymes responsible for lipid mobilization, including PNPLA7. Lysophosphatidic Acid and Sphingosine-1-phosphate are other crucial lipid signaling molecules that influence lipid storage and turnover, thereby affecting PNPLA7 activation.

Curcumin and Retinoic Acid add another layer to this chemical classification. These compounds modulate lipid metabolism through different receptor-mediated pathways. Curcumin has a broad impact on lipid metabolism and can thereby lead to the activation of PNPLA7 for triglyceride hydrolysis. Retinoic Acid, through its influence on retinoid receptors, also plays a role in lipid metabolism, leading to increased PNPLA7 activity. Both of these compounds, among others, serve to maintain lipid homeostasis, and their mechanisms of action can lead to the indirect activation of PNPLA7.