PME-1 Inhibitors

PME-1 inhibitors encompass a range of compounds that influence the activity of Protein Phosphatase Methylesterase-1, either directly or indirectly, by modulating associated enzymatic pathways. The primary function of PME-1 is to demethylate and inactivate PP2A, a significant phosphatase in cellular signaling. Therefore, inhibitors of PME-1 can indirectly enhance PP2A activity, impacting various cellular processes. The list includes compounds like Sinefungin and adenosine derivatives, which are known to affect methyltransferase activities. These molecules may indirectly influence PME-1 function, as PME-1 is involved in the methylation-demethylation equilibrium of PP2A. Similarly, molecules like Methylthioadenosine and its derivatives could act as competitive inhibitors or influence the methylation status of PP2A.

Compounds such as Fostriecin represent a different approach, where instead of inhibiting PME-1, they activate PP2A. This strategy can counteract the inactivation of PP2A by PME-1. In contrast, chemicals like Cantharidin, Okadaic Acid, and Microcystin-LR are PP2A inhibitors, included in the list to provide a broader perspective on the regulation of PP2A and its associated enzymes. These compounds illustrate the complexity of targeting specific phosphatase pathways and the indirect approaches that might be necessary to modulate enzymes like PME-1.