PLC γ2 Activators
Common PLC γ2 Activators include, but are not limited to Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Ionomycin free acid CAS 56092-81-0, Forskolin CAS 66575-29-9, Imatinib CAS 152459-95-5 and U-0126 CAS 109511-58-2.
Phospholipase C gamma 2 (PLC γ2) is an isozyme of the phospholipase C family, which are enzymes known for their role in intracellular signal transduction. PLC enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2), a membrane phospholipid, to generate two crucial secondary messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). These secondary messengers subsequently modulate a variety of cellular responses, including calcium mobilization, protein kinase activation, and gene expression. PLC γ2, in particular, is distinguished from other PLC family members by its direct regulation through receptor tyrosine kinases and non-receptor tyrosine kinases. It plays a pivotal role in several signaling pathways, especially in hematopoietic cells, and is crucial for processes like platelet activation, mast cell development, and B-cell signaling.
PLC γ2 Activators represents a set of chemical compounds specifically designed to enhance the activity of PLC γ2. By amplifying the enzymatic function of PLC γ2, these activators can elevate the levels of IP3 and DAG in cells, consequently amplifying the downstream signaling events they regulate. This augmentation can influence a wide range of cellular processes associated with PLC γ2, from cellular proliferation and differentiation to migration and immune responses. The exploration and characterization of PLC γ2 activators provide valuable insights into the intricacies of cellular signaling pathways mediated by this enzyme, furthering our understanding of its role in cellular physiology and signal transduction mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS activates immune cells, which could lead to the upregulation of signaling proteins like PLC γ2 as part of the activation process. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which is downstream of PLC γ2. Activation of this pathway might stimulate PLC γ2 expression. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
By elevating intracellular calcium levels, ionomycin can mimic the effects of PLC activation and potentially increase PLC γ2 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cAMP levels, which can modulate various signaling pathways and potentially influence PLC γ2 expression. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
This kinase inhibitor affects various signaling pathways in hematopoietic cells, potentially modulating PLC γ2 expression. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
As a PI3K inhibitor, wortmannin can modulate pathways that intersect with PLC γ2, potentially influencing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can affect cell differentiation and signaling, potentially modulating PLC γ2 expression. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
This calcium chelator can affect calcium-dependent signaling pathways, potentially influencing PLC γ2 expression. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
As an immunosuppressant, cyclosporin A can modulate immune cell signaling, potentially affecting PLC γ2 expression. | ||||||