pki β Activators
PKI β Activators are a class of chemical compounds that specifically interact with a subset of protein kinase inhibitors (PKIs). Protein kinase inhibitors, in general, are molecules that can modulate the activity of protein kinases, which are enzymes critical in regulating various cellular processes by phosphorylating specific proteins. The 'β' in their name often indicates a specific target or a particular molecular interaction site within the broad spectrum of protein kinase-related pathways. Activators, as opposed to inhibitors, are designed to increase or enhance the activity of their target enzymes or proteins rather than suppress them.
The molecular mechanisms of PKI β Activators involve complex interactions with the regulatory domains of protein kinases or their associated proteins. These interactions can lead to conformational changes in the target proteins, which may result in the stabilization of an active state or the facilitation of protein-protein interactions necessary for the activation of certain signaling cascades. The precise biochemical pathways and the nature of these interactions are subject to extensive research and are critical for understanding the fundamental processes that govern cell function and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, thereby elevating intracellular cAMP levels. This elevation can lead to an increase in PKA activity, which may then trigger a homeostatic upsurge in PKIβ expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
By mimicking adrenaline, isoproterenol targets β-adrenergic receptors, causing an elevation in cAMP. This surge could initiate a compensatory rise in PKIβ expression to balance PKA signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits various phosphodiesterases, preventing cAMP breakdown, which in turn could lead to an upregulation of PKIβ as a response to increased PKA activity catalyzed by elevated cAMP levels. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
As a PDE4 inhibitor, Rolipram selectively blocks the degradation of cAMP within certain tissues, potentially triggering an upswing in PKIβ expression to counteract the consequent rise in PKA activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
This lipid mediator can stimulate adenylate cyclase via its receptors, leading to a cAMP surge. The cellular response could include the induction of PKIβ expression to maintain equilibrium in PKA-dependent pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine engages with adrenergic receptors, stimulating a cascade that raises cAMP levels. This increase might drive a compensatory induction of PKIβ to ensure cellular homeostasis. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, by binding to its receptors, prompts an increase in cAMP, which could stimulate an adaptive upsurge in the expression of PKIβ to balance the heightened PKA signaling. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Through its A2 receptors, adenosine can stimulate an increase in cAMP. The resulting enhanced PKA activity could prompt a rise in PKIβ expression to counterbalance the signaling cascade. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
By engaging H2 receptors, histamine can stimulate a rise in cAMP. This biochemical response may include the induction of PKIβ expression, serving as a check on the increased PKA activity. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline, as a phosphodiesterase inhibitor, induces an increase in cAMP by preventing its degradation. This rise could precipitate an upregulation in PKIβ expression to balance the augmented PKA signaling. | ||||||