PKI β Activators are a class of chemical compounds that specifically interact with a subset of protein kinase inhibitors (PKIs). Protein kinase inhibitors, in general, are molecules that can modulate the activity of protein kinases, which are enzymes critical in regulating various cellular processes by phosphorylating specific proteins. The 'β' in their name often indicates a specific target or a particular molecular interaction site within the broad spectrum of protein kinase-related pathways. Activators, as opposed to inhibitors, are designed to increase or enhance the activity of their target enzymes or proteins rather than suppress them.
The molecular mechanisms of PKI β Activators involve complex interactions with the regulatory domains of protein kinases or their associated proteins. These interactions can lead to conformational changes in the target proteins, which may result in the stabilization of an active state or the facilitation of protein-protein interactions necessary for the activation of certain signaling cascades. The precise biochemical pathways and the nature of these interactions are subject to extensive research and are critical for understanding the fundamental processes that govern cell function and regulation.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
佛司可林直接刺激腺苷酸环化酶,从而提高细胞内cAMP水平。这种升高会导致PKA活性增加,进而引发PKIβ表达的稳态激增。 | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
通过模拟肾上腺素,异丙肾上腺素以β-肾上腺素能受体为目标,导致cAMP升高。这种激增可能引发 PKIβ 表达的补偿性上升,以平衡 PKA 信号传导。 | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX 可抑制各种磷酸二酯酶,防止 cAMP 分解,进而导致 PKIβ 上调,以应对 cAMP 水平升高催化的 PKA 活性增加。 | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
作为PDE4抑制剂,Rolipram可选择性地阻断某些组织内cAMP的降解,从而可能引发PKIβ表达上升,抵消PKA活性随之上升的影响。 | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
这种脂质介质可以通过其受体刺激腺苷酸环化酶,导致cAMP激增。细胞反应可能包括诱导PKIβ表达,以维持PKA依赖性途径的平衡。 | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
肾上腺素与肾上腺素能受体结合,刺激级联反应,提高 cAMP 水平。这种增加可能会驱动 PKIβ 的补偿性诱导,以确保细胞的平衡。 | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
多巴胺通过与其受体结合,促使 cAMP 增加,这可能会刺激 PKIβ 的适应性表达激增,以平衡增强的 PKA 信号传导。 | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
腺苷可通过其 A2 受体刺激 cAMP 的增加。由此产生的 PKA 活性增强可能会促使 PKIβ 表达增加,以平衡信号级联。 | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
组胺通过与 H2 受体结合,可刺激 cAMP 上升。这种生化反应可能包括诱导 PKIβ 的表达,从而抑制 PKA 活性的增加。 | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
茶碱作为一种磷酸二酯酶抑制剂,通过防止cAMP降解来增加其含量。这种增加可能会促使PKIβ表达上调,从而平衡增强的PKA信号。 |