pierce 1 Activators
PIERCE1 activators predominantly function by manipulating microtubule dynamics, creating cellular conditions that either induce or necessitate PIERCE1's involvement in axonemal stabilization and outer dynein arm attachment. Agents like paclitaxel and epothilone B function by stabilizing microtubules, thereby supporting axonemal structures essential for motile cilia function. Their action indirectly necessitates the stabilization role of PIERCE1 in the axoneme.
In contrast, compounds like colchicine, nocodazole, and vincristine destabilize microtubules, indirectly engaging PIERCE1 by creating a scenario where reformation and stabilization of axonemal microtubules are essential for ciliary motility. By disrupting the equilibrium of microtubule assembly and disassembly, these chemicals induce a cellular state where PIERCE1's role becomes critical for restoring axonemal integrity and facilitating ciliary motion.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules by binding to β-tubulin, enhancing cilia axoneme formation. An intact axoneme can facilitate PIERCE1 action in the attachment of ODAs to DMTs. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Microtubule-depolymerizing agent that indirectly activates PIERCE1 by freeing tubulin units which may increase the dynamicity of cilia axonemes and thus require PIERCE1 for stabilization. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules by interfering with polymerization. This creates a state that necessitates PIERCE1 for the reformation and stabilization of axonemal microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Interferes with microtubule assembly, leading to increased demand for PIERCE1 in re-establishing axonemal integrity. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Stabilizes microtubules similarly to paclitaxel but with different binding dynamics, enhancing axoneme stability and thus requiring proper PIERCE1 function. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Binds to microtubule-associated proteins, causing depolymerization and subsequent requirement for PIERCE1 for dynein arm attachment. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule dynamics by interacting with polymerizing ends, increasing the need for PIERCE1's stabilizing action on dynein-decorated doublet microtubules. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Binds to tubulin at the rhizoxin binding site, destabilizing axonemal microtubules, necessitating PIERCE1's role in attachment of outer dynein arms. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Destabilizes microtubules by binding to colchicine site, creating an environment that requires PIERCE1's role for axonemal re-formation. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Stabilizes microtubules by promoting tubulin assembly, supporting axonemal structures where PIERCE1 exerts its function. | ||||||