Date published: 2026-1-25

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PI 3-kinase p110 gamma Inhibitors

Santa Cruz Biotechnology now offers a broad range of PI 3-kinase p110 gamma Inhibitors for use in various applications. PI 3-kinase p110 gamma inhibitors are critical tools for studying the specific functions of the p110 gamma catalytic subunit of phosphoinositide 3-kinase (PI3K), which plays a key role in regulating immune cell signaling, migration, and inflammation. These inhibitors selectively target the p110 gamma isoform, allowing researchers to dissect its role in various cellular processes and to differentiate its functions from those of other PI3K isoforms. In scientific research, PI 3-kinase p110 gamma inhibitors are utilized to explore the molecular mechanisms of PI3K signaling pathways in leukocytes, such as neutrophils, macrophages, and T cells. Researchers employ these inhibitors to investigate the downstream effects on signaling molecules like AKT, mTOR, and GSK-3, which are pivotal in modulating immune responses, cell survival, and metabolism. By using PI 3-kinase p110 gamma inhibitors, scientists can develop detailed models to investigate the regulatory networks that control immune cell function and the broader implications for immune system regulation. This research is crucial for advancing our understanding of the specific contributions of p110 gamma in immune cell biology and its potential as a target for modulating immune responses in various experimental settings. View detailed information on our available PI 3-kinase p110 gamma Inhibitors by clicking on the product name.

Items 21 to 23 of 23 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Compound 15e

371943-05-4sc-202551
sc-202551A
1 mg
5 mg
$51.00
$206.00
(0)

Compound 15e is a selective inhibitor of the p110 gamma isoform of PI3-kinase, characterized by its unique molecular interactions that promote a conformational shift in the enzyme. This compound effectively alters the enzyme's affinity for phosphoinositides, leading to a significant reduction in lipid phosphorylation. Its reaction kinetics suggest a competitive inhibition model, impacting the enzyme's catalytic efficiency and influencing cellular signaling dynamics.

PIK-293

900185-01-5sc-364585
sc-364585A
5 mg
50 mg
$370.00
$1950.00
(0)

PIK-293 is a highly selective inhibitor targeting the p110 gamma isoform of PI3-kinase, distinguished by its ability to disrupt key protein-lipid interactions. This compound induces a notable alteration in the enzyme's active site, which affects substrate binding and alters downstream signaling pathways. Its kinetic profile indicates a non-competitive inhibition mechanism, thereby modulating the enzyme's activity without directly competing with the substrate, ultimately influencing cellular responses.

PIK-75, free base

372196-67-3sc-394297
5 mg
$83.00
1
(0)

PIK-75, free base, is a selective inhibitor of the p110 gamma isoform of PI3-kinase, characterized by its unique ability to stabilize the inactive conformation of the enzyme. This stabilization disrupts critical protein-protein interactions, leading to a significant reduction in lipid phosphorylation. The compound exhibits a distinct allosteric modulation, influencing the enzyme's conformational dynamics and altering its catalytic efficiency, thereby impacting various cellular signaling cascades.