Date published: 2025-9-5

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Photoreactive Crosslinkers

Santa Cruz Biotechnology now offers a broad range of photoreactive crosslinkers for use in various applications. Photoreactive crosslinkers are versatile compounds used to study the spatial and temporal interactions between biomolecules. These crosslinkers contain photoactivatable groups that, upon exposure to UV light, form covalent bonds with nearby molecules. This property makes them invaluable for capturing transient and weak interactions that are otherwise difficult to study. Researchers use photoreactive crosslinkers to map protein-protein, protein-DNA, and protein-RNA interactions, providing detailed insights into the complex networks that regulate cellular functions. These crosslinkers are also employed in structural biology to stabilize protein complexes for analysis by techniques such as X-ray crystallography and cryo-electron microscopy. Additionally, photoreactive crosslinkers are used in the development of biomaterials, where they facilitate the creation of stable and functionalized surfaces. By offering a comprehensive selection of high-quality photoreactive crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to perform precise and reproducible experiments, driving innovations in understanding molecular interactions and developing new technologies. View detailed information on our available photoreactive crosslinkers by clicking on the product name.

Items 21 to 30 of 31 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SDA (NHS-Diazirine)

sc-397278
50 mg
$437.00
(1)

SDA (NHS-Diazirine) is a photoreactive crosslinker characterized by its diazirine group, which facilitates unique covalent bonding upon exposure to light. This compound exhibits rapid reaction kinetics, enabling efficient crosslinking through the formation of reactive carbene intermediates. Its distinct molecular structure enhances its ability to interact with diverse functional groups, promoting robust network formation. Additionally, SDA's stability under ambient conditions makes it suitable for various applications in material science.

LC-SDA (NHS-LC-Diazirine)

sc-397279
50 mg
$800.00
(0)

LC-SDA (NHS-LC-Diazirine) is a versatile photoreactive crosslinker featuring a diazirine moiety that enables selective covalent attachment upon UV irradiation. Its unique reactivity profile allows for the generation of transient carbene species, which can engage in diverse molecular interactions. The compound's extended linker enhances spatial flexibility, facilitating targeted crosslinking in complex environments. Furthermore, LC-SDA's compatibility with various substrates promotes the formation of intricate polymer networks, making it a valuable tool in advanced material synthesis.

SDAD (NHS-SS-Diazirine)

sc-397280
25 mg
$593.00
(0)

SDAD (NHS-SS-Diazirine) is a specialized photoreactive crosslinker characterized by its unique diazirine structure, which undergoes rapid photolysis upon UV exposure. This process generates highly reactive carbene intermediates, enabling efficient covalent bonding with nucleophiles. The presence of a disulfide linkage enhances its stability and allows for controlled release mechanisms. Additionally, SDAD's ability to form crosslinks in diverse chemical environments makes it an effective agent for creating complex, three-dimensional networks.

Sulfo-SDA (Sulfo-NHS-Diazirine)

sc-397281
50 mg
$361.00
(0)

Sulfo-SDA (Sulfo-NHS-Diazirine) is a versatile photoreactive crosslinker distinguished by its diazirine moiety, which facilitates rapid formation of reactive carbene species upon UV irradiation. This reactivity allows for selective covalent attachment to various nucleophiles, promoting intricate molecular interactions. Its sulfonate group enhances solubility in aqueous environments, broadening its applicability. The compound's unique kinetics enable precise control over crosslinking dynamics, making it ideal for constructing tailored polymeric architectures.

Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine)

sc-397283
50 mg
$541.00
(0)

Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine) is a specialized photoreactive crosslinker characterized by its ability to generate highly reactive carbene intermediates upon exposure to light. This property enables efficient and specific covalent bonding with a range of nucleophiles, facilitating complex molecular networks. The linker’s extended structure enhances flexibility and spatial arrangement, allowing for dynamic interactions in diverse environments. Its unique reactivity profile supports innovative approaches in material science and bioconjugation.

Sulfo-SDAD (Sulfo-NHS-SS-Diazirine)

sc-397284
50 mg
$764.00
(0)

Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) is a versatile photoreactive crosslinker known for its unique disulfide bond, which provides stability and reversible linkage under specific conditions. Upon UV activation, it generates reactive diazirine species that readily engage with nucleophilic sites, enabling precise targeting in complex systems. Its hydrophilic nature enhances solubility in aqueous environments, promoting effective interactions in biological and synthetic matrices. This crosslinker’s distinct reactivity and structural features make it a powerful tool for creating intricate molecular architectures.

L-Photo-Leucine

sc-397286
100 mg
$700.00
(0)

L-Photo-Leucine is a specialized photoreactive crosslinker characterized by its unique ability to form covalent bonds upon exposure to light. Its structure facilitates specific interactions with amino acids, allowing for selective crosslinking in diverse environments. The compound exhibits rapid reaction kinetics, enabling efficient formation of stable linkages. Additionally, its hydrophobic properties contribute to enhanced compatibility with various polymeric systems, making it ideal for creating complex networks in materials science.

L-Photo-Methionine

sc-397287
100 mg
$1000.00
(0)

L-Photo-Methionine is a distinctive photoreactive crosslinker known for its ability to engage in light-induced covalent bonding. Its sulfur-containing side chain enables unique interactions with thiol groups, promoting selective crosslinking in biomolecular assemblies. The compound demonstrates notable reaction kinetics, allowing for swift network formation. Furthermore, its amphiphilic nature enhances solubility in diverse solvents, facilitating integration into various polymer matrices for advanced material applications.

Benzophenone-4-carboxamidocysteine Methanethiosulfonate

317821-69-5sc-217724
10 mg
$367.00
(0)

Benzophenone-4-carboxamidocysteine Methanethiosulfonate is a specialized photoreactive crosslinker that exhibits unique reactivity under UV light, enabling the formation of stable covalent bonds through its methanethiosulfonate moiety. This compound facilitates specific interactions with thiol groups, leading to tailored crosslinking in complex systems. Its distinct photochemical properties allow for controlled reaction kinetics, making it suitable for precise material engineering and structural modifications in various applications.

4-[3-(Trifluoromethyl)diazirin-3-yl]benzoic Acid N-Hydroxysuccinimide Ester

87736-89-8sc-209897A
sc-209897
sc-209897B
sc-209897C
sc-209897D
1 mg
2.5 mg
5 mg
10 mg
25 mg
$230.00
$290.00
$513.00
$940.00
$2000.00
(0)

4-[3-(Trifluoromethyl)diazirin-3-yl]benzoic Acid N-Hydroxysuccinimide Ester is a versatile photoreactive crosslinker characterized by its diazirine moiety, which undergoes rapid cycloaddition upon UV irradiation. This compound exhibits high selectivity for nucleophiles, enabling efficient covalent bond formation with amines and other reactive groups. Its trifluoromethyl substitution enhances stability and solubility, while facilitating unique molecular interactions that allow for precise control over crosslinking dynamics in diverse experimental setups.