Peroxin 3 Inhibitors
Peroxin 3 inhibitors belong to a distinctive chemical class characterized by their ability to modulate the function of peroxin 3, a crucial protein involved in the biogenesis and maintenance of peroxisomes. Peroxisomes are membrane-bound organelles found in eukaryotic cells, known for their involvement in various metabolic processes, including lipid metabolism and detoxification reactions. Peroxin 3, also referred to as PEX3, plays a pivotal role in peroxisomal membrane assembly and protein import, facilitating the proper functioning of peroxisomes within the cellular environment.
The inhibitors targeting peroxin 3 typically exert their effects by disrupting the interactions between PEX3 and other peroxins, hindering the assembly of functional peroxisomal membranes. This interference may occur at various stages of peroxisome biogenesis, ultimately leading to the impairment of peroxisomal functions. Understanding the structural and biochemical aspects of peroxin 3 inhibitors is crucial for unraveling their mode of action. Researchers have explored the three-dimensional architecture of PEX3 and its binding sites, providing valuable insights into the design and development of inhibitors with enhanced specificity and efficacy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW6471 | 880635-03-0 | sc-300779 | 5 mg | $295.00 | 9 | |
A PPAR alpha antagonist that can disrupt peroxisome proliferator-activated receptor pathways, indirectly affecting peroxisomal biogenesis and PEX3 function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Known to interfere with peroxisome assembly by disrupting membrane structures, which could impair PEX3 integration into the peroxisomal membrane. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that can alter gene expression, potentially affecting PEX3 levels and peroxisome assembly. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
An HMG-CoA reductase inhibitor that can lead to altered prenylation of proteins, potentially affecting peroxisomal membrane protein interactions, including PEX3. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Similar to Lovastatin, it may affect peroxisomal membrane stability and protein localization, indirectly affecting PEX3. | ||||||
10-Undecynoic acid | 2777-65-3 | sc-223142 sc-223142A | 1 g 5 g | $27.00 $86.00 | ||
An inhibitor of fatty acid metabolism that can affect peroxisomal functions, potentially altering the environment in which PEX3 operates. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $188.00 | ||
Inhibits mitochondrial carnitine palmitoyltransferase, which may shift fatty acid metabolism and indirectly impact peroxisomal function and PEX3. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Another HMG-CoA reductase inhibitor that may disrupt peroxisomal lipid metabolism and indirectly affect PEX3's role in peroxisome biogenesis. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Known to disrupt various cellular functions; it could alter peroxisome biogenesis and indirectly affect PEX3. | ||||||