PDE4C Inhibitors
Phosphodiesterase 4C (PDE4C) inhibitors belong to a distinctive chemical class known for their specific interactions with the PDE4C enzyme. PDE4C is a member of the phosphodiesterase enzyme family, which plays a crucial role in cellular signal transduction by regulating the levels of intracellular cyclic adenosine monophosphate (cAMP). PDE4C, in particular, is primarily expressed in immune cells, where it modulates inflammatory responses and immune cell functions. The inhibitors targeting PDE4C are designed to selectively bind and inhibit the enzymatic activity of PDE4C, thus influencing downstream cellular processes regulated by cAMP.
PDE4C inhibitors are characterized by their ability to interact with the catalytic site of the PDE4C enzyme, disrupting the hydrolysis of cAMP into its inactive form. This inhibition results in an accumulation of cAMP within the cell, leading to altered cellular signaling cascades and, consequently, impacting immune responses. The development of PDE4C inhibitors involves a meticulous understanding of the enzyme's structural features, as well as the design of small molecules that can specifically bind to the active site of PDE4C. The quest for selective inhibitors is crucial to minimize off-target effects, as other members of the PDE4 family may be present in various tissues and play different roles in cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roflumilast | 162401-32-3 | sc-208313 | 5 mg | $60.00 | 21 | |
Roflumilast is a selective inhibitor of PDE4C known to reduce the activity of this enzyme, leading to an increase in the intracellular levels of cyclic AMP (cAMP). | ||||||
Ibudilast | 50847-11-5 | sc-203080 | 10 mg | $218.00 | 1 | |
While not selective, Ibudilast can inhibit PDE4C. It suppresses the enzyme's activity, which results in increased intracellular cAMP levels. | ||||||
Apremilast | 608141-41-9 | sc-480062 | 5 mg | $444.00 | ||
Apremilast is another PDE4C inhibitor that acts by increasing cAMP levels in cells by reducing the activity of this enzyme. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a PDE4C inhibitor that works by suppressing the enzyme's activity, thus increasing intracellular levels of cAMP. | ||||||
Piclamilast | 144035-83-6 | sc-478653 | 5 mg | $300.00 | ||
Piclamilast is a selective PDE4C inhibitor that increases intracellular cAMP levels by inhibiting the activity of this enzyme. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a PDE4C inhibitor that works by reducing the activity of this enzyme, resulting in an increase in the intracellular levels of cAMP. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin, a naturally occurring flavonoid, can inhibit PDE4C. It reduces the enzyme's activity, leading to increased intracellular levels of cAMP. | ||||||
Diphenhydramine hydrochloride | 147-24-0 | sc-204729 sc-204729A sc-204729B | 10 g 25 g 100 g | $52.00 $84.00 $124.00 | 4 | |
Diphenhydramine hydrochloride, although not selective for PDE4C, can inhibit this enzyme. It works by reducing its activity, leading to an increase in intracellular cAMP levels. | ||||||