Date published: 2025-12-24

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PDE4A1 Inhibitors

Santa Cruz Biotechnology now offers a broad range of PDE4A1 Inhibitors for use in various applications. PDE4A1 Inhibitors are crucial tools in the study of phosphodiesterase 4A1 (PDE4A1), an enzyme that specifically hydrolyzes cyclic adenosine monophosphate (cAMP) into AMP, thereby regulating intracellular levels of this important second messenger. By inhibiting PDE4A1, these compounds increase cAMP concentrations, influencing various cellular processes such as gene expression, inflammation, and synaptic plasticity. The ability to modulate cAMP levels with PDE4A1 Inhibitors allows researchers to investigate the detailed mechanisms of cAMP-dependent signaling pathways. This has significant implications for understanding how cells respond to hormonal signals, manage energy balance, and regulate immune responses. In scientific research, PDE4A1 Inhibitors are utilized to explore the role of cAMP in different cellular contexts, such as its impact on neuronal function, memory formation, and neuroprotection. Additionally, these inhibitors are used in studies of inflammatory processes, given that elevated cAMP levels can modulate the activity of immune cells and reduce the production of pro-inflammatory cytokines. By providing insights into the biochemical pathways influenced by PDE4A1, these inhibitors support the development of novel strategies for manipulating cellular signaling for research purposes. View detailed information on our available PDE4A1 Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
$75.00
$212.00
18
(1)

Rolipram functions as a selective inhibitor of phosphodiesterase 4A1 (PDE4A1), characterized by its ability to disrupt the enzyme's catalytic activity through specific hydrophobic interactions and electrostatic forces. This results in altered reaction kinetics, enhancing the stability of cyclic AMP levels within cells. The compound's unique structural features allow for precise interactions with the enzyme's active site, influencing downstream signaling cascades and cellular responses.