PC-PLD3 Inhibitors
PC-PLD3 inhibitors belong to a class of chemical compounds that have garnered attention in the fields of molecular biology and pharmacology due to modulating specific cellular processes. PC-PLD3, or Phosphatidylcholine-Phospholipase D3, is an enzyme that plays a crucial role in lipid metabolism, specifically in the hydrolysis of phosphatidylcholine (PC) to generate choline and phosphatidic acid (PA). This enzyme is primarily localized within cellular membranes, where it participates in the regulation of lipid composition and signaling processes. Phosphatidic acid, one of the products of PC-PLD3 activity, serves as a precursor for the synthesis of other lipid molecules, such as diacylglycerol (DAG) and lysophosphatidic acid (LPA), both of which are involved in various cellular signaling pathways. PC-PLD3 inhibitors are designed to interact with the active site or binding domain of the PC-PLD3 enzyme, effectively inhibiting its function and influencing cellular processes dependent on PC-PLD3-mediated lipid metabolism and signaling.
Structurally, PC-PLD3 inhibitors are engineered to selectively target the active site or binding domains of PC-PLD3, ensuring high specificity for this particular lipid-metabolizing enzyme. By inhibiting PC-PLD3, these compounds may disrupt its role in the hydrolysis of phosphatidylcholine, leading to alterations in lipid composition and the production of downstream signaling molecules like phosphatidic acid. The study of PC-PLD3 inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions related to lipid metabolism, membrane dynamics, and signal transduction pathways. This knowledge contributes to our understanding of basic cell biology and may have implications in various research areas, including lipid biochemistry, cellular physiology, and the molecular basis of diseases associated with dysregulated lipid metabolism and signaling. However, further research is required to fully explore the extent of their applications and their impact on cellular physiology in the context of PC-PLD3-mediated lipid metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may inhibit gene transcription globally, which could decrease PLD3 mRNA levels as a secondary effect. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid is known to affect nuclear factor-kappa B (NF-κB) signaling, potentially reducing PLD3 gene expression. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A has been shown to disrupt transcriptional regulation, which might lead to decreased expression of PLD3. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can influence multiple signaling pathways, potentially leading to altered transcription and decreased PLD3 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 inhibits the proteasome, which might affect the stability of transcription factors and subsequently decrease PLD3 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide can cause DNA damage, potentially triggering responses that lead to reduced transcription of certain genes, possibly including PLD3. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can cause demethylation of gene promoters, potentially affecting PLD3 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase, potentially altering chromatin structure and gene expression, including PLD3. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid affects gene expression by activating nuclear receptors, which could modulate PLD3 transcription. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to reduced DNA synthesis and potential downregulation of PLD3 expression. | ||||||