PARP-12 Inhibitors
PARP-12 inhibitors constitute a class of chemical compounds that have garnered increasing interest in the field of molecular biology and cellular research. These inhibitors are designed to target the enzymatic activity of PARP-12, a member of the PARP (Poly ADP-ribose polymerase) enzyme family. PARP-12, also known as ARTD12, plays a role in various cellular processes, including DNA repair, genomic stability, and the maintenance of cellular homeostasis. Inhibition of PARP-12 can be achieved through various chemical compounds that disrupt its catalytic function, making them invaluable tools in the study of PARP-12's role in cellular physiology.
The chemical diversity within the PARP-12 inhibitors class is notable, as it encompasses a range of compounds, from small molecules to more complex agents. These inhibitors are specifically designed to interact with the catalytic domain of PARP-12, thereby interfering with its ability to poly ADP-ribosylate target proteins and modulate cellular responses. While some inhibitors may have selectivity for PARP-12, others may exhibit cross-reactivity with other PARP family members. The study of PARP-12 inhibitors is essential for elucidating the precise functions and downstream effects of PARP-12 activation, shedding light on its role in cellular processes and implications in various biological contexts. Additionally, the development and application of PARP-12 inhibitors contribute to the broader understanding of the PARP enzyme family and its significance in cell biology and molecular research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one | 1174043-16-3 | sc-497005 | 5 mg | $430.00 | ||
AZD2461 is an experimental PARP-12 inhibitor developed by AstraZeneca. It is designed to target PARP-12's enzymatic activity and is being investigated for its potential role in cancer therapy. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib, another PARP inhibitor, has been reported to exhibit some activity against PARP-12. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
While rucaparib primarily targets other PARP family members, it may also have some activity against PARP-12. | ||||||
Niraparib | 1038915-60-4 | sc-507492 | 10 mg | $150.00 | ||
Niraparib primarily targets other PARP enzymes, however it may also affect PARP-12 to some extent. | ||||||
ABT-888 | 912445-05-7 | sc-202901 sc-202901A sc-202901B | 1 mg 5 mg 25 mg | $115.00 $170.00 $500.00 | 24 | |
Veliparib is being investigated in research trials for its potential use in cancer therapy. While its primary targets are other PARP family members, it may have some cross-reactivity with PARP-12. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
Talazoparib is a PARP inhibitor with activity against multiple PARP family members, including PARP-It is studied in the research of certain breast cancers and is being studied for other indications. | ||||||
3-Aminobenzamide | 3544-24-9 | sc-3501 sc-3501B sc-3501A | 100 mg 1 g 5 g | $15.00 $36.00 $51.00 | 18 | |
3-AB is a non-specific PARP inhibitor that can inhibit various PARP family members, including PARP-It has been used in laboratory studies to explore PARP-12's functions. | ||||||
NU 1025 | 90417-38-2 | sc-203166 | 5 mg | $131.00 | 9 | |
NU1025 is another non-specific PARP inhibitor used in research to study various PARP enzymes, including PARP-12. | ||||||
PARP Inhibitor VIII, PJ34 | 344458-15-7 | sc-204161 sc-204161A | 1 mg 5 mg | $57.00 $139.00 | 20 | |
PJ34 is a PARP inhibitor that exhibits activity against multiple PARP family members, including PARP-It has been employed in scientific investigations to elucidate the functions of PARP-12. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $178.00 $270.00 $712.00 | 3 | |
ABT-888 is another name for Veliparib, which has already been mentioned. It is used in research trials and research studies to assess its potential as a PARP-12 inhibitor along with its broader PARP inhibition properties. | ||||||