PAM Inhibitors
PAM inhibitors, short for Positive Allosteric Modulator inhibitors, represent a class of compounds in the field of pharmacology and biochemistry. These chemical entities are specifically designed to target and interact with positive allosteric modulators (PAMs), which are molecules that enhance the activity of certain receptors or enzymes within the body. PAMs themselves are vital in regulating various biological processes by potentiating the effects of their target proteins. However, PAM inhibitors are engineered to exert the opposite effect, inhibiting the action of PAMs and thereby modulating the activity of the associated receptor or enzyme.
PAM inhibitors is centered around their ability to bind to the same allosteric site on the target protein as the PAM itself. This binding disrupts the PAM's ability to enhance the protein's activity, resulting in a decrease in the overall function of the receptor or enzyme. This modulation can have significant implications for various physiological processes, including signal transduction pathways and neurotransmitter systems. Researchers have been studying PAM inhibitors to gain a deeper understanding of their effects on specific biological targets.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Bromohexadecanoic acid | 18263-25-7 | sc-251714 sc-251714A | 10 g 50 g | $53.00 $201.00 | 4 | |
Acts as a palmitoylation inhibitor, thereby potentially inhibiting PAM through disruption of its palmitoylation-dependent localization and function. | ||||||
ET-18-OCH3 | 77286-66-9 | sc-201021 sc-201021A sc-201021B sc-201021C sc-201021F | 5 mg 25 mg 50 mg 100 mg 1 g | $111.00 $436.00 $843.00 $1576.00 $3756.00 | 6 | |
A synthetic alkyl-lysophospholipid that disrupts lipid rafts, possibly affecting PAM localization and its interactions with other proteins. | ||||||
Hydroxylamine solution | 7803-49-8 | sc-250136 | 100 ml | $72.00 | ||
Reacts with the ester bonds in lipid-modified proteins, potentially altering PAM's palmitoylation state and its activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
A glycosylation inhibitor that can indirectly affect PAM by disrupting the maturation of proteins that interact with or regulate PAM. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Inhibits fatty acid synthase, which can lead to a reduction in palmitic acid, a substrate necessary for PAM's palmitoylation function. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Inhibits long-chain acyl-CoA synthetase, decreasing the availability of acyl-CoAs, potentially impacting PAM's activity. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $200.00 $680.00 | 18 | |
Inhibits ceramide synthase, which can alter sphingolipid metabolism, thereby potentially affecting the function and localization of PAM. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Inhibits Ras farnesyltransferase, which can indirectly affect PAM function by altering the prenylation and localization of proteins that interact with PAM. | ||||||