PABPC1L Activators
PABPC1L, poly(A) binding protein cytoplasmic 1-like, plays a critical role in regulating mRNA stability and translation, key processes in cellular function and gene expression. It binds to the poly(A) tail of mRNA molecules, influencing their stability and the efficiency of translation, essential for protein synthesis. This protein is implicated in the intricate network of RNA processing and regulation, serving as a nexus for signals that dictate mRNA fate and thus protein production within the cell. Its activity and regulation are essential for proper cellular function, including responses to developmental cues and stress, underscoring the importance of understanding mechanisms that can activate or enhance its function.
Activation of PABPC1L involves complex interactions within cellular signaling pathways that influence its ability to bind RNA and participate in mRNA metabolism. The mechanisms of activation are multifaceted, involving post-translational modifications such as phosphorylation, alterations in cellular localization, and interactions with other proteins and RNA molecules. Given its central role in mRNA processing, strategies to activate PABPC1L could impact global protein synthesis patterns, influencing cell growth, differentiation, and response to environmental signals. Theoretical activators, therefore, target processes that modulate these interactions and the cellular environment, aiming to enhance PABPC1L's role in mRNA stability and translation. Research into these activators and their effects on PABPC1L will further elucidate the protein's function and its potential as a target for modulating gene expression at the post-transcriptional level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP promotes protein kinase A (PKA) activity, which can enhance phosphorylation states of various proteins, potentially enhancing PABPC1L function in mRNA stabilization and translation regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a nonspecific inhibitor of phosphodiesterases, prevents cAMP degradation. This elevation in cAMP could similarly enhance PKA activity, possibly contributing to an environment that supports PABPC1L activation through post-translational modifications. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, by inhibiting PDE4, elevates intracellular cAMP levels, which could indirectly activate PABPC1L through PKA-mediated pathways, possibly affecting PABPC1L's role in mRNA poly(A) tail length regulation and stability. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, through its antioxidant properties, may support cellular environments that favor PABPC1L activation by reducing oxidative stress, potentially enhancing PABPC1L's interaction with mRNA and its stabilization activities. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates multiple signaling pathways, including NF-κB, which could indirectly enhance PABPC1L function by influencing inflammatory responses and possibly affecting mRNA stabilization mechanisms that PABPC1L is involved in. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which may indirectly support PABPC1L activation through deacetylation of proteins involved in mRNA metabolic processes, potentially affecting mRNA stability and translation in which PABPC1L plays a role. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, alters chromatin structure, potentially affecting the cellular localization and function of PABPC1L by promoting a transcriptionally active state that supports mRNA processing activities. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to an increase in cAMP levels, which might indirectly promote PABPC1L activation through enhanced PKA signaling, potentially influencing mRNA stability and translation processes. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose, a glycolysis inhibitor, may create cellular conditions that favor PABPC1L activation by altering energy metabolism, possibly impacting PABPC1L's role in adaptive responses to metabolic stress in mRNA processing. | ||||||
Zinc sulfate solution | 7733-02-0 | sc-251451 | 250 ml | $110.00 | ||
Zinc, as an essential mineral, can act as a cofactor for various enzymes and could indirectly support PABPC1L function by stabilizing RNA binding domains or facilitating molecular interactions essential for mRNA processing. | ||||||