OTUD2 Inhibitors
OTUD2 inhibitors are a class of small molecules and compounds that target a specific protein known as OTUD2, or ovarian tumor domain-containing 2. OTUD2, also referred to as Cezanne, is a deubiquitinase enzyme that plays a crucial role in the regulation of various cellular processes. Deubiquitinases are enzymes responsible for removing ubiquitin molecules from other proteins, thereby modulating their stability, activity, and localization within the cell. OTUD2 specifically cleaves K11-linked polyubiquitin chains and is involved in the control of various signaling pathways, including those related to inflammation, DNA repair, and cell cycle regulation.
OTUD2 inhibitors is of significant interest in the field of molecular biology and cellular signaling research. By selectively inhibiting the activity of OTUD2, these compounds can help elucidate the precise functions and downstream effects of OTUD2-mediated deubiquitination in various cellular contexts. This inhibition can result in the stabilization or degradation of specific target proteins, which can in turn affect cellular processes and signaling cascades. Researchers use OTUD2 inhibitors as valuable tools to better understand the intricate regulatory mechanisms governed by ubiquitination and deubiquitination.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can increase ubiquitinated proteins indirectly affecting OTUD2's substrate availability. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Another proteasome inhibitor that can lead to an accumulation of ubiquitinated proteins, indirectly diminishing OTUD2 activity. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An inhibitor of the ubiquitin-activating enzyme E1, could indirectly reduce the ubiquitin-protein conjugates OTUD2 may act upon. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
A specific inhibitor of the deubiquitinase USP14, which could shift the ubiquitin-protein homeostasis affecting OTUD2-related pathways. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
A deubiquitinase inhibitor that affects multiple DUBs and thereby could indirectly impact OTUD2's functional interplay with ubiquitinated substrates. | ||||||
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $165.00 | ||
An inhibitor of USP7 and USP47, which could indirectly affect OTUD2's activity by modulating ubiquitination levels. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
A broad-spectrum deubiquitinase inhibitor, which could have an impact on the cellular processes involving OTUD2. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
A dual Ubc13/Uev1A E2 enzyme inhibitor, which may indirectly affect OTUD2 activity through the ubiquitination pathway. | ||||||